Evidence map›Paper›PMID 29437920›Full record

ArticlemBio2018

Genomic Analysis of Hospital Plumbing Reveals Diverse Reservoir of Bacterial Plasmids Conferring Carbapenem Resistance.

Rebecca A Weingarten, Ryan C Johnson, Sean Conlan, Amanda M Ramsburg, John P Dekker, Anna F Lau, Pavel Khil, Robin T Odom, Clay Deming, Morgan Park and 6 more

Open access · goldAbstract read
In one paragraph

Article in mBio, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 122 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
122citing papers in PubMed, 1 pooled it
9.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

122 citing papers in PubMed, 1 synthesis or guideline pooled it, 218 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. TnMicrobial genomics · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Molecular Insights into Carbapenem Resistance inInternational journal of molecular sciences · 2026
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Plasmid diversity ofMicrobiology spectrum · 2025
    Article
  18. Article
  19. Review
  20. A persistent sink reservoir as a potential source ofAntimicrobial stewardship & healthcare epidemiology : ASHE · 2025
    Article

62 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 1 country.

Rebecca A Weingarten *National Institutes of Health Clinical Center, Bethesda, Maryland, USA.
Ryan C Johnson *National Human Genome Research Institute, Bethesda, Maryland, USA.
Sean Conlan *National Human Genome Research Institute, Bethesda, Maryland, USA.ORCID 0000-0001-6848-3465
Amanda M RamsburgNational Institutes of Health Clinical Center, Bethesda, Maryland, USA.
John P DekkerNational Institutes of Health Clinical Center, Bethesda, Maryland, USA.
Anna F LauNational Institutes of Health Clinical Center, Bethesda, Maryland, USA.
Pavel KhilNational Institutes of Health Clinical Center, Bethesda, Maryland, USA.
Robin T OdomNational Institutes of Health Clinical Center, Bethesda, Maryland, USA.
Clay DemingNational Human Genome Research Institute, Bethesda, Maryland, USA.
Morgan ParkNIH Intramural Sequencing Center, Rockville, Maryland, USA.
Pamela J ThomasNIH Intramural Sequencing Center, Rockville, Maryland, USA.
NISC Comparative Sequencing Program
David K HendersonNational Institutes of Health Clinical Center, Bethesda, Maryland, USA.
Tara N Palmore *National Institutes of Health Clinical Center, Bethesda, Maryland, USA.
Julia A Segre *National Human Genome Research Institute, Bethesda, Maryland, USA.ORCID 0000-0001-6860-348X
Karen M Frank *National Institutes of Health Clinical Center, Bethesda, Maryland, USA karen.frank@nih.gov.
National Institutes of Health Clinical Center · USNational Human Genome Research Institute · USOffice of Extramural Research · US

Funding

Inter- and Intra-Species Comparative SequencingZIBHG000196 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI THOMAS, JAMES · 2009 to 2025
$177.6M
Application of Genomic Approaches to Bacterial Pathogenesis and Mechanisms of Antimicrobial ResistanceZIAAI001249 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI DEKKER, JOHN · 2019 to 2025
$13.7M
Microbial genomics of hospital-associated pathogensZIAHG200382 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI SEGRE, JULIA ANGELA · 2012 to 2025
$9.1M
Environmental Surveillance for BacteriaZIACL010356 · CLC · CLINICAL CENTER · PI FRANK, KAREN · 2016 to 2021
$0k
Novel Diagnostic Platforms for Sterility Testing of Cellular Therapies and Biopharmaceutical ProductsZIACL060092 · CLC · CLINICAL CENTER · PI LAU, ANNA · 2014 to 2025
$0k
Investigation of Horizontal Transfer of Carbapenemase Gene in Gram Negative BacteriaZIACL080018 · CLC · CLINICAL CENTER · PI FRANK, KAREN · 2014 to 2022
$0k
6 · The paper itself

Abstract

The hospital environment is a potential reservoir of bacteria with plasmids conferring carbapenem resistance. Our Hospital Epidemiology Service routinely performs extensive sampling of high-touch surfaces, sinks, and other locations in the hospital. Over a 2-year period, additional sampling was conducted at a broader range of locations, including housekeeping closets, wastewater from hospital internal pipes, and external manholes. We compared these data with previously collected information from 5 years of patient clinical and surveillance isolates. Whole-genome sequencing and analysis of 108 isolates provided comprehensive characterization of

Indexed as

Sanitary EngineeringWater MicrobiologyBacterial Proteinsbeta-LactamasesCarbapenem-Resistant EnterobacteriaceaeHospitalsHumansMetagenomicsPlasmidsPrevalenceWhole Genome SequencingBacterial Proteinsbeta-Lactamasescarbapenemaseantimicrobial resistancecarbapenemase-producing organismscarbapenem resistantenvironmentinfection controlplasmid-mediated resistanceplumbingwastewater

Identifiers

PMID29437920
PMCPMC5801463
OpenAlexW2792564185

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.