ArticleJournal of molecular endocrinology2018
Decidual cell regulation of trophoblast is altered in pregnancies at risk of pre-eclampsia.
Article in Journal of molecular endocrinology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 37 citations in OpenAlex.
- Preimplantation exposure to viral dsRNA impairs decidualization leading to altered placental development and fetal growth restriction.Reproduction & fertility · 2026Article
- Advanced maternal age and assisted reproductive technologies: outcomes, genomics, and real-world evidence.Frontiers in reproductive health · 2026Review
- Senescent Syncytiotrophoblast Secretion During Early Onset Preeclampsia.Hypertension (Dallas, Tex. : 1979) · 2025Article
- Review
- Single-cell profiling reveals immune disturbances landscape and HLA-F-mediated immune tolerance at the maternal-fetal interface in preeclampsia.Frontiers in immunology · 2023Article
- Establishment of the fetal-maternal interface: developmental events in human implantation and placentation.Frontiers in cell and developmental biology · 2023Review
- Placenta Accreta Spectrum Diagnosis Challenges and Controversies in Current Obstetrics: A Review.International journal of women's health · 2023Review
- Mesenchymal Stem Cells-Induced Trophoblast Invasion Is Reduced in Patients with a Previous History of Preeclampsia.International journal of molecular sciences · 2022Article
- (Dis)similarities between the Decidual and Tumor Microenvironment.Biomedicines · 2022Review
- Human placenta-based genome-wide mRNA sequencing to identify TEK/IGF1/CSF1/ANGPT2 as crucial segments in the pathogenesis of pre-eclampsia.Frontiers in genetics · 2022Article
- Single cell RNA sequencing research in maternal fetal interface.Frontiers in cell and developmental biology · 2022Review
- Fas regulates the apoptosis and migration of trophoblast cells by targeting NF-κB.Experimental and therapeutic medicine · 2021Article
- Decreased circUBAP2 Expression Is Associated with Preeclampsia by Limiting Trophoblast Cell Proliferation and Migration.Reproductive sciences (Thousand Oaks, Calif.) · 2021Article
- Lactic Acid: A Novel Signaling Molecule in Early Pregnancy?Frontiers in immunology · 2020Review
- Preeclampsia: The Relationship between Uterine Artery Blood Flow and Trophoblast Function.International journal of molecular sciences · 2019Review
- Genetics and Epigenetics of Infertility and Treatments on Outcomes.The Journal of clinical endocrinology and metabolism · 2019Review
- Extracellular vesicle mediated embryo-endometrial cross talk during implantation and in pregnancy.Journal of assisted reproduction and genetics · 2019Review
- Altered Tryptophan Catabolism in Placentas From Women With Pre-eclampsia.International journal of tryptophan research : IJTR · 2019Article
- Silencing BRIT1 Facilitates the Abilities of Invasiveness and Migration in Trophoblast Cells.Medical science monitor : international medical journal of experimental and clinical research · 2018Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Successful implantation and placentation are dependent on the interaction between decidual stromal cells (DSC) and extravillous trophoblast (EVT) cells. The extent of trophoblast invasion relies on communication between the placenta and maternal decidua. The cyclical process of decidualisation induces a transformation of endometrial fibroblasts to secretory DSC; these secreted products have many functions including the control of trophoblast invasion. Inadequate trophoblast invasion and remodelling of the uterine vessels (the spiral arteries) are associated with pregnancy disorders such as pre-eclampsia. Uterine artery Doppler resistance index (RI) in the first trimester of pregnancy can be used as a proxy measure of remodelling. DSC were isolated from pregnancies with normal (normal RI) or impaired (high RI) spiral artery remodelling. Following isolation, DSC were re-decidualised using cAMP and MPA and secretion of the decidualisation markers IGFBP-1 and prolactin assessed. We examined the impact of DSC-secreted factors on trophoblast cell function, using the EVT cell line SGHPL-4. We demonstrated that DSC exposed to decidual factors were able to re-decidualise
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.