ArticleJournal of molecular endocrinology2018
Curcumin exerts a protective effect against premature ovarian failure in mice.
Article in Journal of molecular endocrinology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
92 citing papers in PubMed, 3 syntheses or guidelines pooled it, 158 citations in OpenAlex.
- Efficacy of natural products on premature ovarian failure: a systematic review and meta-analysis of preclinical studies.Journal of ovarian research · 2024Pooled it
- Curcumin and Polycystic Ovary Syndrome: a Systematic Review.Reproductive sciences (Thousand Oaks, Calif.) · 2022Pooled it
- Induced premature ovarian insufficiency by using D galactose and its effects on reproductive profiles in small laboratory animals: a systematic review.Journal of ovarian research · 2019Pooled it
- Effect of fennel extract on Anti-Müllerian Hormone and sonographic indices in infertile women with occult premature ovarian insufficiency: a randomized controlled clinical trial.BMC complementary medicine and therapies · 2025Trial
- Oxidative Stress in Ovarian Aging and Progress in Chinese Medicine Therapy.Chinese journal of integrative medicine · 2026Review
- Prenatal Chlorpyrifos Exposure Induces Ovarian Toxicity in Rat Offspring: Modulatory Potential of Curcumin.Toxics · 2026Article
- Anti-Aging Effects ofFoods (Basel, Switzerland) · 2026Article
- Amygdalin improves ovarian function by inhibiting oxidative stress and inflammation in premature ovarian failure mice.Histology and histopathology · 2026Article
- A Multidimensional Perspective Review of Traditional Chinese Medicine in Treating Ovarian Aging.International journal of women's health · 2026Review
- Preventing ovarian aging: from redox-targeted strategies to extracellular vesicle-based therapies.Frontiers in aging · 2026Review
- Bioactive natural products predominantly derived from Chinese herbal medicines for diminished ovarian reserve: mechanistic insights into ovarian protection.Frontiers in endocrinology · 2026Review
- Lemongrass (Biochemistry research international · 2026Article
- Association between PFAS compounds in follicular fluid and POR and the intervention effect of Qizi Yusi Tang: a study based on targeted PFAS quantification analysis.Frontiers in endocrinology · 2026Article
- Curcumin's Therapeutic Potential in Ovarian Cancer: Current Insights and Future Perspectives.Food science & nutrition · 2025Review
- Efficacy and safety of nutritional supplements in female infertility: a network meta-analysis.Reproductive biology and endocrinology : RB&E · 2025Review
- Role and mechanisms of plant polyphenols in ovarian aging.Journal of ovarian research · 2025Review
- Modulatory effect of quercetin on premature ovarian insufficiency induced by cyclophosphamide via the PARP1 and GSK3β.Scientific reports · 2025Article
- Metabolomics Analysis on the Effect ofAntioxidants (Basel, Switzerland) · 2025Article
- Nano-curcumin potentially ameliorates hormonal function and follicular counts following the vitrification and transplantation of rat ovarian tissue.Scientific reports · 2025Article
- Curcumin Alleviates HMGB1-Mediated Inflammation Through the Signaling Pathway ofInternational journal of molecular sciences · 2025Article
32 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study was designed to investigate the protective effect of curcumin against d-galactose (d-gal)-induced premature ovarian failure (POF) in mice. A mouse POF model was induced by subcutaneous injection of d-gal (200 mg/kg/day) daily for 42 days. Mice in the curcumin group received both d-gal treatment and intraperitoneal injection of curcumin (100 mg/kg/day) for 42 days. Ovarian function, oxidative stress and apoptosis were evaluated. The P, E2 and SOD levels were higher, and the FSH, LH and MDA levels were significantly lower in the curcumin group than those in the d-gal group. The proportion of primordial follicles was also significantly higher in the curcumin group than that in the d-gal group. In addition, curcumin treatment after d-gal administration resulted in significantly lower
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.