Evidence map›Paper›PMID 29437826›Full record

ArticleGenetics2018

RNA-Interference Pathways Display High Rates of Adaptive Protein Evolution in Multiple Invertebrates.

William H Palmer, Jarrod D Hadfield, Darren J Obbard

Open access · bronzeAbstract read
In one paragraph

Article in Genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 1 pooled it
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 1 synthesis or guideline pooled it, 93 citations in OpenAlex.

  1. Pooled it
  2. Article
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  4. Short- and long-term costs of reproduction revealed by telomere dynamics in wild greater horseshoe bats.Proceedings of the National Academy of Sciences of the United States of America · 2025
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  11. Maintenance of persistent transmission of a plant arbovirus in its insect vector mediated by the Toll-Dorsal immune pathway.Proceedings of the National Academy of Sciences of the United States of America · 2024
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  16. Review
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  19. RNA interference is essential to modulating the pathogenesis of mosquito-borne viruses in the yellow fever mosquitoProceedings of the National Academy of Sciences of the United States of America · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

William H PalmerInstitute of Evolutionary Biology, University of Edinburgh, EH9 3FL, United Kingdom w.h.palmer@sms.ed.ac.uk.
Jarrod D HadfieldInstitute of Evolutionary Biology, University of Edinburgh, EH9 3FL, United Kingdom.
Darren J ObbardInstitute of Evolutionary Biology, University of Edinburgh, EH9 3FL, United Kingdom.ORCID 0000-0001-5392-8142
University of Edinburgh · GB

Funding

Wellcome TrustWellcome Trust WT095831
6 · The paper itself

Abstract

Conflict between organisms can lead to a reciprocal adaptation that manifests as an increased evolutionary rate in genes mediating the conflict. This adaptive signature has been observed in RNA-interference (RNAi) pathway genes involved in the suppression of viruses and transposable elements in

Indexed as

Evolution, MolecularGene Expression RegulationRNA InterferenceSignal TransductionAdaptation, BiologicalAnimalsDNA Transposable ElementsDrosophilaGene SilencingGenetics, PopulationHost-Pathogen InteractionsInsectaInvertebratesNematodaRNA, Small InterferingSelection, GeneticDNA Transposable ElementsRNA, Small Interferingadaptive evolutionantiviral immunitypopulation geneticsRNA interferencesmall RNAtransposable elementsviruses

Identifiers

PMID29437826
PMCPMC5887150
OpenAlexW2949593181

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.