ArticleCirculation. Arrhythmia and electrophysiology2018
Altered Repolarization Reserve in Failing Rabbit Ventricular Myocytes: Calcium and β-Adrenergic Effects on Delayed- and Inward-Rectifier Potassium Currents.
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Article in Circulation. Arrhythmia and electrophysiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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30citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
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30 citing papers in PubMed, 39 citations in OpenAlex.
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- Role of dynamical instability in QT interval variability and early afterdepolarization propensity.Biophysical journal · 2025Article
- Immune cells and arrhythmias.Cardiovascular research · 2025Review
- Optogenetic quantification of cardiac excitability and electrical coupling in intact hearts to explain cardiac arrhythmia initiation.Science advances · 2025Article
- Beta-Adrenergic Activation of the Inward Rectifier KInternational journal of molecular sciences · 2024Article
- Ion channel trafficking implications in heart failure.Frontiers in cardiovascular medicine · 2024Review
- Caveolin-3 and Caveolae regulate ventricular repolarization.Journal of molecular and cellular cardiology · 2023Article
- Protein Kinase D1 Regulates Cardiac Hypertrophy, Potassium Channel Remodeling, and Arrhythmias in Heart Failure.Journal of the American Heart Association · 2022Article
- Tetramisole is a new IPharmacology research & perspectives · 2022Review
- Methadone Blockade of Cardiac Inward Rectifier KJournal of the American Heart Association · 2022Article
- Pharmacological suppression of Nedd4-2 rescues the reduction of Kv11.1 channels in pathological cardiac hypertrophy.Frontiers in pharmacology · 2022Article
- Protective Effect of Trimetazidine on Potassium Ion Homeostasis in Myocardial Tissue in Mice with Heart Failure.BioMed research international · 2022Article
- Two-hit mechanism of cardiac arrhythmias in diabetic hyperglycaemia: reduced repolarization reserve, neurohormonal stimulation, and heart failure exacerbate susceptibility.Cardiovascular research · 2021Article
- Specific protein kinase C isoform exerts chronic inhibition on the slowly activating delayed-rectifier potassium current by affecting channel trafficking.Channels (Austin, Tex.) · 2021Article
- Cardiomyocyte NaBasic research in cardiology · 2021Article
- Review
- Regulatory mechanism of calcium/calmodulin-dependent protein kinase II in the occurrence and development of ventricular arrhythmia (Review).Experimental and therapeutic medicine · 2021Review
- Hyperglycemia regulates cardiac KBasic research in cardiology · 2020Article
- CaMKIIδC Drives Early Adaptive CaCirculation research · 2020Article
- Balance Between Rapid Delayed Rectifier KCirculation. Arrhythmia and electrophysiology · 2020Article
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Authors and funding
10 authors at 1 institution in 1 country.
Bence HegyiFrom the Department of Pharmacology (B.H., J.B., K.S.G., L.T.I., Y.C.-I., D.M.B.), School of Medicine, Dean's Office (L.T.), Surgical Research Facility, School of Medicine (W.T.F.), Department of Biomedical Engineering (Y.C.-I.), Department of Internal Medicine/Cardiology (Y.C.-I.), University of California, Davis; Echocardiography Laboratory, University of California, Davis Medical Center, Sacramento (L.M.M.); and Department of Medicine, University of Alabama at Birmingham (S.M.P.).
Julie BossuytFrom the Department of Pharmacology (B.H., J.B., K.S.G., L.T.I., Y.C.-I., D.M.B.), School of Medicine, Dean's Office (L.T.), Surgical Research Facility, School of Medicine (W.T.F.), Department of Biomedical Engineering (Y.C.-I.), Department of Internal Medicine/Cardiology (Y.C.-I.), University of California, Davis; Echocardiography Laboratory, University of California, Davis Medical Center, Sacramento (L.M.M.); and Department of Medicine, University of Alabama at Birmingham (S.M.P.).
Kenneth S GinsburgFrom the Department of Pharmacology (B.H., J.B., K.S.G., L.T.I., Y.C.-I., D.M.B.), School of Medicine, Dean's Office (L.T.), Surgical Research Facility, School of Medicine (W.T.F.), Department of Biomedical Engineering (Y.C.-I.), Department of Internal Medicine/Cardiology (Y.C.-I.), University of California, Davis; Echocardiography Laboratory, University of California, Davis Medical Center, Sacramento (L.M.M.); and Department of Medicine, University of Alabama at Birmingham (S.M.P.).
Lynette M MendozaFrom the Department of Pharmacology (B.H., J.B., K.S.G., L.T.I., Y.C.-I., D.M.B.), School of Medicine, Dean's Office (L.T.), Surgical Research Facility, School of Medicine (W.T.F.), Department of Biomedical Engineering (Y.C.-I.), Department of Internal Medicine/Cardiology (Y.C.-I.), University of California, Davis; Echocardiography Laboratory, University of California, Davis Medical Center, Sacramento (L.M.M.); and Department of Medicine, University of Alabama at Birmingham (S.M.P.).
Linda TalkenFrom the Department of Pharmacology (B.H., J.B., K.S.G., L.T.I., Y.C.-I., D.M.B.), School of Medicine, Dean's Office (L.T.), Surgical Research Facility, School of Medicine (W.T.F.), Department of Biomedical Engineering (Y.C.-I.), Department of Internal Medicine/Cardiology (Y.C.-I.), University of California, Davis; Echocardiography Laboratory, University of California, Davis Medical Center, Sacramento (L.M.M.); and Department of Medicine, University of Alabama at Birmingham (S.M.P.).
William T FerrierFrom the Department of Pharmacology (B.H., J.B., K.S.G., L.T.I., Y.C.-I., D.M.B.), School of Medicine, Dean's Office (L.T.), Surgical Research Facility, School of Medicine (W.T.F.), Department of Biomedical Engineering (Y.C.-I.), Department of Internal Medicine/Cardiology (Y.C.-I.), University of California, Davis; Echocardiography Laboratory, University of California, Davis Medical Center, Sacramento (L.M.M.); and Department of Medicine, University of Alabama at Birmingham (S.M.P.).
Steven M PogwizdFrom the Department of Pharmacology (B.H., J.B., K.S.G., L.T.I., Y.C.-I., D.M.B.), School of Medicine, Dean's Office (L.T.), Surgical Research Facility, School of Medicine (W.T.F.), Department of Biomedical Engineering (Y.C.-I.), Department of Internal Medicine/Cardiology (Y.C.-I.), University of California, Davis; Echocardiography Laboratory, University of California, Davis Medical Center, Sacramento (L.M.M.); and Department of Medicine, University of Alabama at Birmingham (S.M.P.).
Leighton T IzuFrom the Department of Pharmacology (B.H., J.B., K.S.G., L.T.I., Y.C.-I., D.M.B.), School of Medicine, Dean's Office (L.T.), Surgical Research Facility, School of Medicine (W.T.F.), Department of Biomedical Engineering (Y.C.-I.), Department of Internal Medicine/Cardiology (Y.C.-I.), University of California, Davis; Echocardiography Laboratory, University of California, Davis Medical Center, Sacramento (L.M.M.); and Department of Medicine, University of Alabama at Birmingham (S.M.P.).
Ye Chen-IzuFrom the Department of Pharmacology (B.H., J.B., K.S.G., L.T.I., Y.C.-I., D.M.B.), School of Medicine, Dean's Office (L.T.), Surgical Research Facility, School of Medicine (W.T.F.), Department of Biomedical Engineering (Y.C.-I.), Department of Internal Medicine/Cardiology (Y.C.-I.), University of California, Davis; Echocardiography Laboratory, University of California, Davis Medical Center, Sacramento (L.M.M.); and Department of Medicine, University of Alabama at Birmingham (S.M.P.).
Donald M BersFrom the Department of Pharmacology (B.H., J.B., K.S.G., L.T.I., Y.C.-I., D.M.B.), School of Medicine, Dean's Office (L.T.), Surgical Research Facility, School of Medicine (W.T.F.), Department of Biomedical Engineering (Y.C.-I.), Department of Internal Medicine/Cardiology (Y.C.-I.), University of California, Davis; Echocardiography Laboratory, University of California, Davis Medical Center, Sacramento (L.M.M.); and Department of Medicine, University of Alabama at Birmingham (S.M.P.). dmbers@ucdavis.edu.
University of California Davis Medical Center · US
Funding
Program AdministrationP01HL080101 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BERS, DONALD M · 2006 to 2015
$23.4MPathophysiological Regulation of Cardiac Myocyte RyR ChannelR01HL092097 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Donald M Bers, Robyn T Rebbeck · 2010 to 2026
$9.3MIONIC CONTROL OF CARDIAC MUSCLE CONTRACTION: EC COUPLINGR01HL030077 · NHLBI · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI BERS, DONALD M · 1986 to 2018
$3.8MAKAP-dependent regulation of Cardiac SR Ca handlingR01HL133832 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BERS, DONALD M · 2017 to 2020
$2.0MNovel Cell-in-Gel System for Mechanotransduction Study at the Single Cell LevelR01HL123526 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHEN-IZU, YE · 2015 to 2018
$1.8MSarcomere Length Shortening and the Destabilization of the Ca2+ Control System inR01HL090880 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI IZU, LEIGHTON T. · 2009 to 2012
$1.5MNHLBI NIH HHS P01 HL080101NHLBI NIH HHS R01 HL030077NHLBI NIH HHS R01 HL090880NHLBI NIH HHS R01 HL092097NHLBI NIH HHS R01 HL123526NHLBI NIH HHS R01 HL133832
Abstract
backgroundElectrophysiological remodeling and increased susceptibility for cardiac arrhythmias are hallmarks of heart failure (HF). Ventricular action potential duration (APD) is typically prolonged in HF, with reduced repolarization reserve. However, underlying K METHODS AND
resultsWe measured the major K
conclusionsAt baseline Ca
Indexed as
Action PotentialsAdrenergic beta-AgonistsAnimalsCalciumDisease Models, AnimalHeart FailureHeart VentriclesMaleMyocytes, CardiacPotassiumRabbitsAdrenergic beta-AgonistsCalciumPotassiumaction potentialcalcium/calmodulin-dependent protein kinase IIelectrophysiologyheart failurepotassium channels
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.