Trial reportJournal of the American Heart Association2018
Bilateral Transcutaneous Electrical Nerve Stimulation Improves Lower-Limb Motor Function in Subjects With Chronic Stroke: A Randomized Controlled Trial.
Trial report in Journal of the American Heart Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02152813 (Efficacy of Bilateral Stimulation With Task-oriented Training in Improving Lower Limb Motor Functions in Patients With Stroke), which is not on this map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Efficacy of Bilateral Stimulation With Task-oriented Training in Improving Lower Limb Motor Functions in Patients With Stroke: a Randomized, Placebo-controlled Clinical Trial
Who cites it
18 citing papers in PubMed.
- Comparison of Continuous and Gait-synchronized Transcutaneous Electrical Nerve Stimulation During Gait Training in Chronic Stroke: A Pilot Randomized Trial.Revista de neurologia · 2026Trial
- Transauricular Vagus Nerve Stimulation in Acute Ischaemic Stroke Requiring Mechanical Thrombectomy: Sham-Controlled, Randomised Device Trial.Translational stroke research · 2025Trial
- A sham-controlled randomised trial evaluating the safety, acceptability, and efficacy of autonomic neuromodulation using transcutaneous vagal sensory stimulation in uncontrolled hypertensive patients: rationale and study design of the SCRATCH-HTN study.Frontiers in cardiovascular medicine · 2026Article
- Neuromechanical Predictors of Clinical Scores of Balance and Functional Mobility in Chronic Stroke Survivors - A Machine Learning Approach.medRxiv : the preprint server for health sciences · 2025Article
- Post-Stroke Rehabilitation: Neurophysiology Processes of Bilateral Movement Training and Interlimb Coupling-A Systematic Review.Journal of clinical medicine · 2025Review
- Neuroplasticity and Nervous System Recovery: Cellular Mechanisms, Therapeutic Advances, and Future Prospects.Brain sciences · 2025Review
- Spatial Distribution Dynamics of Sensory Disturbances in the Treatment of Obesity-Related Meralgia Paresthetica Using Transcutaneous Electrical Nerve Stimulation.Journal of clinical medicine · 2025Article
- Comparative effects of 2 Hz vs. 100 Hz transcutaneous electrical nerve stimulation on upper limb motor function post-stroke: design and rationale for a randomized trial.Frontiers in neurology · 2025Article
- Functional Recovery and Regenerative Effects of Direct Transcutaneous Electrical Nerve Stimulation in Treatment of Post-COVID-19 Guillain-Barré and Acute Transverse Myelitis Overlap Syndrome: A Clinical Case.Journal of functional morphology and kinesiology · 2024Article
- Assessing the fall risk with Stay Independent Questionnaire in people with stroke.Frontiers in neurology · 2024Article
- Article
- Transcutaneous Electrical Nerve Stimulation (TENS) Alleviates Brain Ischemic Injury by Regulating Neuronal Oxidative Stress, Pyroptosis, and Mitophagy.Mediators of inflammation · 2023Article
- A scoping review of the contralateral effects of unilateral peripheral stimulation on neuromuscular function.PloS one · 2022Article
- Sensory electrical stimulation and postural balance: a comprehensive review.European journal of applied physiology · 2021Review
- Grey Relational Analysis of Lower Limb Muscle Fatigue and Pedalling Performance Decline of Elite Athletes during a 30-Second All-Out Sprint Cycling Exercise.Journal of healthcare engineering · 2021Article
- Rewiring the Lesioned Brain: Electrical Stimulation for Post-Stroke Motor Restoration.Journal of stroke · 2020Review
- Activation of the primary motor cortex using fully-implanted electrical sciatic nerve stimulation.Experimental and therapeutic medicine · 2019Article
- Efficacy of functional electrical stimulation at different frequencies for post-stroke foot drop: a retrospective cohort study.Frontiers in neurologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTranscutaneous electrical nerve stimulation (TENS) has been used to augment the efficacy of task-oriented training (TOT) after stroke. Bilateral intervention approaches have also been shown to be effective in augmenting motor function after stroke. The purpose of this study was to compare the efficacy of bilateral TENS combined with TOT versus unilateral TENS combined with TOT in improving lower-limb motor function in subjects with chronic stroke. METHODS AND
resultsEighty subjects were randomly assigned to bilateral TENS+TOT or to unilateral TENS+TOT and underwent 20 sessions of training over a 10-week period. The outcome measures included the maximal strength of the lower-limb muscles and the results of the Lower Extremity Motor Coordination Test, Berg Balance Scale, Step Test, and Timed Up and Go test. Each participant was assessed at baseline, after 10 and 20 sessions of training and 3 months after the cessation of training. The subjects in the bilateral TENS+TOT group showed greater improvement in paretic ankle dorsiflexion strength (β=1.32;
conclusionsThe application of bilateral TENS over the common peroneal nerve combined with TOT was superior to the application of unilateral TENS combined with TOT in improving paretic ankle dorsiflexion strength after 10 sessions of training and in improving the completion time for the Timed Up and Go test after 20 sessions of training. CLINICAL
trial registrationURL: http://www.clinicaltrials.gov. Unique identifier: NCT02152813.
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Registered trials
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