ArticleAnnals of the rheumatic diseases2018
Baseline ultrasound examination as possible predictor of relapse in patients affected by juvenile idiopathic arthritis (JIA).
Article in Annals of the rheumatic diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.
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Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 65 citations in OpenAlex.
- The role of ultrasonography in assessing remission in juvenile idiopathic arthritis: a systematic review.European journal of pediatrics · 2023Pooled it
- Treatment Withdrawal Following Remission in Juvenile Idiopathic Arthritis: A Systematic Review of the Literature.Paediatric drugs · 2019Pooled it
- Reliability of CEUS and MRI for grading knee-joint inflammation in juvenile idiopathic arthritis.European radiology · 2026Article
- From Hands to Imaging: The Emerging Role of Musculoskeletal Ultrasonography in Juvenile Idiopathic Arthritis Disease Activity Assessment.International journal of rheumatic diseases · 2026Article
- Validation of a semi-quantitative ultrasonography score for knee synovitis in juvenile idiopathic arthritis and its association with clinical findings.Advances in rheumatology (London, England) · 2026Article
- [Advances in ultrasound diagnostics in children with rheumatic diseases].Zeitschrift fur Rheumatologie · 2026Review
- Toward Personalized Withdrawal of TNF-α Inhibitors in Non-Systemic Juvenile Idiopathic Arthritis: Predictors of Biologic-Free Remission and Flare.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Development and validation of subtype-specific simplified ultrasound assessment systems for juvenile idiopathic arthritis: a prospective observational study.Frontiers in pediatrics · 2026Article
- Novel insights into the biology of childhood arthritis- lessons learned from the synovium.Arthritis research & therapy · 2025Review
- [Rheumatic shoulder joints in childhood].Zeitschrift fur Rheumatologie · 2025Article
- Evaluation of ILAR and PRINTO classifications for juvenile idiopathic arthritis: oligoarticular JIA vs early-onset ANA-positive JIA.Clinical rheumatology · 2025Article
- Sonographic and Disease Activity Findings Related With Medication Change in JIA: A Historical Cohort Study.Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases · 2025Article
- A clinical perspective on imaging in juvenile idiopathic arthritis.Pediatric radiology · 2024Review
- Diagnostic Accuracy Study of the Pediatric-Specific Ultrasound Scoring System for the Knee Joint in Children With Juvenile Idiopathic Arthritis.Arthritis care & research · 2024Article
- The importance of ultrasound examination in care of juvenile idiopathic arthritis patients: 9 months follow-up study.Frontiers in pediatrics · 2024Article
- Musculoskeletal Ultrasound and the Assessment of Disease Activity in Juvenile Idiopathic Arthritis.Arthritis care & research · 2023Article
- Musculoskeletal Ultrasound in Childhood Arthritis Limited Examination: A Comprehensive, Reliable, Time-Efficient Assessment of Synovitis.Arthritis care & research · 2023Article
- Reliability of the Pediatric Specific Musculoskeletal Ultrasound Scoring Systems for the Elbow, Wrist, and Finger Joints.The Journal of rheumatology · 2023Article
- Predictive Value of Magnetic Resonance Imaging in Patients With Juvenile Idiopathic Arthritis in Clinical Remission.Arthritis care & research · 2023Article
- Contribution of Ultrasound in Current Practice for Managing Juvenile Idiopathic Arthritis.Journal of clinical medicine · 2022Review
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Authors and funding
13 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo define the correlation between joint ultrasonography and clinical examination in patients with juvenile idiopathic arthritis (JIA) and to assess whether synovitis detected by ultrasonography in clinically inactive patients predicts arthritis flares.
methods88 consecutive patients with JIA-46 (52%) with persistent oligoarthritis, 15 (17%) with extended oligoarthritis, 15 (17%) with rheumatoid factor-negative polyarthritis and 12 (14%) with other forms of JIA, all clinically inactive for a minimum of 3 months-underwent ultrasound (US) assessment of 44 joints. Joints were scanned at study entry for synovial hyperplasia, joint effusion and power Doppler (PD) signal. Patients were followed clinically for 4 years.
resultsUS was abnormal in 20/88 (22.7%) patients and in 38/3872 (0.98%) joints. Extended oligoarthritis and rheumatoid factor-negative polyarthritis were more frequent in US-positive than in US-negative patients (35.0% vs 11.8% and 30.0% vs 13.2%, respectively; P=0.005). During 4 years of follow-up, 41/88 (46.6%) patients displayed a flare; 26/68 (38.2%) were US-negative and 15/20 (75%) were US-positive at baseline. Abnormality on US examination, after correction for therapy modification, significantly increased the risk of flare (OR=3.8, 95% CI 1.2 to 11.5). The combination of grey scale and PD abnormalities displayed a much higher predictive value of relapse (65%, 13/20) than grey scale alone (33%, 6/18).
conclusionsUS abnormalities are a strong predictor of relapse at individual patient level. Irrespective of treatment, the risk of flare in US-positive versus US-negative patients was almost four times higher. In case of US abnormalities, patients should be carefully followed regardless of both the International League of Associations for Rheumatology and Wallace categories.
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