ArticleEnvironmental science & technology2018
Household Dust as a Repository of Chemical Accumulation: New Insights from a Comprehensive High-Resolution Mass Spectrometric Study.
Article in Environmental science & technology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Standard Reference Material (SRM®) 1950 metabolites in frozen human plasma-use, impact, lessons learned, and future perspectives.Analytical and bioanalytical chemistry · 2026Review
- Evaluation of peak alignment performance of commercial and open-source tools for GC×GC-MS based non-targeted screening.Briefings in bioinformatics · 2026Article
- Environmental factors influencing hormone receptor positive breast cancer incidence: integrating chemical signatures from dust wipes with self-reported sources of exposure.Journal of exposure science & environmental epidemiology · 2026Article
- Applying Nontargeted Analysis to Explore the Chemical Composition of Dust Collected in Infants' Homes.Environmental science & technology · 2025Article
- Article
- Comprehensive characterization of European house dust contaminants: Concentrations and profiles, geographical variability, and implications for chemical regulation and health risk.The Science of the total environment · 2024Article
- Insights into the Chemical Exposome during Pregnancy: A Non-Targeted Analysis of Preterm and Term Births.Environmental science & technology · 2024Article
- Modeling the relative response factor of small molecules in positive electrospray ionization.RSC advances · 2024Article
- Exploring applications of non-targeted analysis in the characterization of the prenatal exposome.The Science of the total environment · 2024Article
- Extracting Structural Information from Physicochemical Property Measurements Using Machine Learning─A New Approach for Structure Elucidation in Non-targeted Analysis.Environmental science & technology · 2023Article
- First Novel Workflow for Semiquantification of Emerging Contaminants in Environmental Samples Analyzed by Gas Chromatography-Atmospheric Pressure Chemical Ionization-Quadrupole Time of Flight-Mass Spectrometry.Analytical chemistry · 2022Article
- Article
- Uncertainty estimation strategies for quantitative non-targeted analysis.Analytical and bioanalytical chemistry · 2022Article
- Sorption and migration of organophosphate flame retardants between sources and settled dust.Chemosphere · 2021Article
- A Comprehensive Non-targeted Analysis Study of the Prenatal Exposome.Environmental science & technology · 2021Article
- Do flame retardant concentrations change in dust after older upholstered furniture is replaced?Environment international · 2021Article
- Using Estrogenic Activity and Nontargeted Chemical Analysis to Identify Contaminants in Sewage Sludge.Environmental science & technology · 2021Article
- Evaluating couch polyurethane foam for a potential passive sampler of semivolatile organic compounds.Chemosphere · 2021Article
- Temporal variability of indoor dust concentrations of semivolatile organic compounds.Indoor air · 2021Article
- Suspect Screening, Prioritization, and Confirmation of Environmental Chemicals in Maternal-Newborn Pairs from San Francisco.Environmental science & technology · 2021Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Chemical exposure in household dust poses potential risks to human health but has been studied incompletely thus far. Most analytical studies have focused on one or several compound classes, with analysis performed by either liquid or gas chromatography coupled with mass spectrometry (LC-MS or GC-MS). However, a comprehensive investigation of individual dust samples is missing. The present study comprehensively characterizes chemicals in dust by applying a combination of target, suspect, and nontarget screening approaches using both LC and GC with quadrupole time-of-flight (Q/TOF) MS. First, the extraction method was optimized to streamline detection of LC-Q/TOF and GC-Q/TOF amenable compounds and was successfully validated with over 100 target compounds. Nontarget screening with GC-Q/TOF was done by spectral deconvolution followed by a library search. Suspect screening by LC-Q/TOF was carried out with an accurate mass spectral library. Finally, LC-Q/TOF nontarget screening was carried out by extracting molecular features, acquiring tandem mass spectrometric (MS/MS) spectra, and performing compound identification by use of in silico fragmentation software tools. In total, 271 chemicals could be detected in 38 dust samples, 163 of which could be unambiguously confirmed by a reference standard. Many of them, such as the plastic leachable 7,9-di- tert-butyl-1-oxaspiro(4,5)deca-6,9-diene-2,8-dione (CAS 82304-66-3) and three organofluorine compounds, are of emerging concern and their presence in dust has been underestimated. Advantages and drawbacks of the different approaches and analytical instruments are critically discussed.
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