ArticleJournal of biomedical materials research. Part B, Applied biomaterials2018
Formation of osteon-like structures in unidirectional porous hydroxyapatite substitute.
Article in Journal of biomedical materials research. Part B, Applied biomaterials, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 12 citations in OpenAlex.
- Clinical Application of Unidirectional Porous Hydroxyapatite to Bone Tumor Surgery and Other Orthopedic Surgery.Biomimetics (Basel, Switzerland) · 2024Review
- The Role of Vasculature and Angiogenic Strategies in Bone Regeneration.Biomimetics (Basel, Switzerland) · 2024Review
- Effects of Channels and Micropores in Honeycomb Scaffolds on the Reconstruction of Segmental Bone Defects.Frontiers in bioengineering and biotechnology · 2022Article
- A Complex Evaluation of the In-Vivo Biocompatibility and Degradation of an Extruded ZnMgSr Absorbable Alloy Implanted into Rabbit Bones for 360 Days.International journal of molecular sciences · 2021Article
- Unidirectional porous beta-tricalcium phosphate and hydroxyapatite artificial bone: a review of experimental evaluations and clinical applications.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2021Review
- Radiographic and clinical assessment of unidirectional porous hydroxyapatite to treat benign bone tumors.Scientific reports · 2020Article
- Angiogenesis and new bone formation in novel unidirectional porous beta-tricalcium phosphate: a histological study.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2019Article
- Formation of osteon-like structures in unidirectional porous hydroxyapatite substitute.Journal of biomedical materials research. Part B, Applied biomaterials · 2018Article
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Unidirectional porous hydroxyapatite (UDPHAp) bone substitute comprises a microstructure of cross-sectionally oval pores with diameters ranging from 30 to 300 µm. Bone remodeling within the UDPHAp is expected upon implantation into bone; however, the mechanism and factors influencing this bone growth remain unclear. The objectives of the present study were to assess the vasculature and microstructure of newly formed bone and to determine how bone formation is affected by load transfer and UDPHAp pore size. Formation of osteon-like structures, defined by the presence of lacunae, canaliculi and a central lumen containing capillaries, was observed within the implanted UDPHAp material in all animals after six weeks. The number of osteocytes and osteon-like structures in areas adjacent to the cortex of recipient bone was significantly higher than in areas next to the medullary cavity throughout the recovery period. Notably, osteon-like structures tended to form in smaller diameter pores. Continuous bone remodeling might be promoted by the rapid formation of unidirectional capillaries and the osteocyte lacunae-canalicular system. Load transfer and smaller pore size could positively affect cortical bone regeneration. © 2018 The Authors Journal of Biomedical Materials Research Part B: Applied Biomaterials Published by Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 2665-2672, 2018.
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