Evidence map›Paper›PMID 29437263›Full record

ArticleImmunology and cell biology2018

Human blood MAIT cell subsets defined using MR1 tetramers.

Nicholas A Gherardin, Michael Nt Souter, Hui-Fern Koay, Kirstie M Mangas, Torsten Seemann, Timothy P Stinear, Sidonia Bg Eckle, Stuart P Berzins, Yves d'Udekem, Igor E Konstantinov and 7 more

Open access · hybridAbstract readComparative Study
In one paragraph

Article in Immunology and cell biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 166 papers.

0numbers the graph read from it
0cells of the map it votes in
166citing papers in PubMed
12.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

166 citing papers in PubMed, 263 citations in OpenAlex.

  1. Gut archaea drive human MAIT cell responses.bioRxiv : the preprint server for biology · 2026
    Article
  2. Single-cell RNA profiling suggests goflikicept-mediated immune modulation in idiopathic recurrent pericarditis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
    Article
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106 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 6 institutions in 1 country.

Nicholas A GherardinDepartment of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC, 3000, Australia.ORCID 0000-0003-4690-2571
Michael Nt SouterDepartment of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC, 3000, Australia.
Hui-Fern KoayDepartment of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC, 3000, Australia.
Kirstie M MangasDepartment of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC, 3000, Australia.
Torsten SeemannLife Sciences Computation Centre, Victorian Life Sciences Computation Initiative, Carlton, VIC, 3053, Australia.
Timothy P StinearDepartment of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC, 3000, Australia.
Sidonia Bg EckleDepartment of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC, 3000, Australia.
Stuart P BerzinsFederation University Australia, Ballarat, VIC, 3350, Australia.
Yves d'UdekemRoyal Children's Hospital, Flemington Road, Parkville, VIC, 3052, Australia.
Igor E KonstantinovRoyal Children's Hospital, Flemington Road, Parkville, VIC, 3052, Australia.
David P FairlieDivision of Chemistry & Structural Biology, Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, 4072, Australia.
David S RitchieCancer Immunology Program, Peter MacCallum Cancer Centre, East Melbourne, VIC, 3002, Australia.
Paul J NeesonCancer Immunology Program, Peter MacCallum Cancer Centre, East Melbourne, VIC, 3002, Australia.
Daniel G PellicciDepartment of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC, 3000, Australia.
Adam P UldrichDepartment of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC, 3000, Australia.
James McCluskeyDepartment of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC, 3000, Australia.
Dale I GodfreyDepartment of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC, 3000, Australia.
The University of Melbourne · AURoyal Children's Hospital · AUFederation University · AUMelbourne Bioinformatics · AUPeter MacCallum Cancer Centre · AUThe University of Queensland · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mucosal-associated invariant T (MAIT) cells represent up to 10% of circulating human T cells. They are usually defined using combinations of non-lineage-specific (surrogate) markers such as anti-TRAV1-2, CD161, IL-18Rα and CD26. The development of MR1-Ag tetramers now permits the specific identification of MAIT cells based on T-cell receptor specificity. Here, we compare these approaches for identifying MAIT cells and show that surrogate markers are not always accurate in identifying these cells, particularly the CD4

Indexed as

AgingBiomarkersBlood CellsCell DifferentiationCells, CulturedCell SeparationCytokinesFlow CytometryHistocompatibility Antigens Class IHumansLymphocyte ActivationMinor Histocompatibility AntigensMucosal-Associated Invariant T CellsNatural Killer T-CellsReceptors, Antigen, T-CellReceptors, Antigen, T-Cell, gamma-deltaBiomarkersCytokinesHistocompatibility Antigens Class IMinor Histocompatibility AntigensMR1 protein, humanReceptors, Antigen, T-CellReceptors, Antigen, T-Cell, gamma-deltaT-cell receptor Vdelta2, humanHuman immunologyMAITMR1T cellunconventional T cell

Identifiers

PMID29437263
PMCPMC6446826
OpenAlexW2790170256

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.