Evidence map›Paper›PMID 29437204›Full record

ArticleCancer2018

Early-stage breast cancer and employment participation after 2 years of follow-up: A comparison with age-matched controls.

Christine C Ekenga, Maria Pérez, Julie A Margenthaler, Donna B Jeffe

Abstract readComparative StudyMulticenter Study
In one paragraph

Article in Cancer, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 6 syntheses or guidelines pooled it.

  1. Pooled it
  2. Prognostic factors for return to work in breast cancer survivors.The Cochrane database of systematic reviews · 2025
    Pooled it
  3. Pooled it
  4. "Chemobrain" in childhood cancer survivors-the impact on social, academic, and daily living skills: a qualitative systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
    Pooled it
  5. Pooled it
  6. Long-term work retention after treatment for cancer: a systematic review and meta-analysis.Journal of cancer survivorship : research and practice · 2020
    Pooled it
  7. Trial
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Characterizing Cancer and Work Disparities Using Electronic Health Records.International journal of environmental research and public health · 2022
    Article
  15. Article
  16. Article
  17. Article
  18. Late effects in a high-risk population of breast cancer survivors.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022
    Article
  19. Disability and remote work during the pandemic with implications for cancer survivors.Journal of cancer survivorship : research and practice · 2022
    Article
  20. Employment disruption among women with gynecologic cancers.International journal of gynecological cancer : official journal of the International Gynecological Cancer Society · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Christine C EkengaBrown School, Washington University in St. Louis, St. Louis, Missouri.ORCID 0000-0002-6209-4888
Maria PérezDepartment of Medicine, Washington University School of Medicine, Washington University in St. Louis, St. Louis, Missouri.
Julie A MargenthalerDepartment of Surgery, Washington University School of Medicine, Washington University in St. Louis, St. Louis, Missouri.
Donna B JeffeDepartment of Medicine, Washington University School of Medicine, Washington University in St. Louis, St. Louis, Missouri.

Funding

Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI AIMEE S JAMES · 2001 to 2026
$128.0M
Pacific Northwest Agricultural Safety and Health Center-RenewalU54OH007544 · OH · UNIVERSITY OF WASHINGTON · PI YOST, MICHAEL G · 2011 to 2025
$23.0M
Healthier Workforce Center of the MidwestU19OH008868 · OH · UNIVERSITY OF IOWA · PI ROHLMAN, DIANE S · 2006 to 2025
$19.8M
Postdoctoral Training in Cancer Prevention and ControlT32CA190194 · NCI · WASHINGTON UNIVERSITY · PI GRAHAM A. COLDITZ, AIMEE S JAMES · 2014 to 2026
$4.7M
Quality of Life Over Time: DCIS vs Early Breast CancerR01CA102777 · NCI · WASHINGTON UNIVERSITY · PI JEFFE, DONNA B · 2003 to 2007
$1.5M
ACL HHS U19OH008868NCI NIH HHS P30 CA091842NCI NIH HHS R01 CA102777NCI NIH HHS T32 CA190194NIOSH CDC HHS U19 OH008868NIOSH CDC HHS U54 OH007544
6 · The paper itself

Abstract

backgroundAlthough cancer survivors are more likely to be unemployed than individuals without a cancer history, employment participation after treatment of early-stage breast cancer has not been widely studied to date. The objectives of the current study were to evaluate employment trajectories in a cohort of patients with early-stage breast cancer and age-matched controls from the time of diagnosis to the 2-year follow-up, and identify factors associated with diminished and emerging employment participation.

methodsAs part of a larger cohort study of 1096 patients with early-stage breast cancer and same-aged women without breast cancer, data from 723 working-age (aged 40-64 years) women (347 patients and 376 controls) were analyzed to evaluate 4 employment trajectories (sustained unemployment, diminished employment, emerging employment, and sustained employment). Multivariable logistic regression models were used to identify factors associated with diminished employment versus sustained employment, and emerging employment versus sustained unemployment.

resultsLower percentages of patients (71%) compared with controls (79%) reported full-time or part-time employment at enrollment (P<.01). Fatigue was a significant predictor of diminished employment for both patients (odds ratio [OR], 5.71; 95% confidence interval [95% CI], 2.48-13.15) and controls (OR, 2.38; 95% CI, 1.21-4.68). Among patients, African American race (OR, 4.02; 95% CI, 1.57-10.28) and public/uninsured insurance status (OR, 4.76; 95% CI, 1.34-12.38) were found to be associated with diminished employment. Among controls, high social support was associated with emerging employment (OR, 3.12; 95% CI, 1.25-7.79).

conclusionsFatigued patients, African American patients, and publicly insured/uninsured patients with cancer were more likely to experience diminished employment after 2 years of follow-up. Further investigation with longer follow-up is warranted to identify factors associated with these disparities in employment participation after treatment of early-stage breast cancer. Cancer 2018;124:2026-35. © 2018 American Cancer Society.

Indexed as

AdultBlack or African AmericanBreast NeoplasmsCancer SurvivorsEmploymentFatigueFemaleHealth Status DisparitiesHumansInsurance CoverageLongitudinal StudiesMiddle AgedMissouriNeoplasm StagingProspective StudiesRetirementbreast canceremploymentfatiguereturn to worksurvivorship

Identifiers

PMID29437204
PMCPMC5910179

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.