Evidence map›Paper›PMID 29437172›Full record

ArticleLab on a chip2018

Closed-loop feedback control for microfluidic systems through automated capacitive fluid height sensing.

L R Soenksen, T Kassis, M Noh, L G Griffith, D L Trumper

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Lab on a chip, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
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  8. Review
  9. Article
  10. Review
  11. A frugal microfluidic pump.Lab on a chip · 2021
    Article
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

L R SoenksenDepartment of Mechanical Engineering, MIT, Cambridge, MA, USA. soenksen@mit.edu and Research Laboratory of Electronics, MIT, Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-7890-7209
T KassisResearch Laboratory of Electronics, MIT, Cambridge, MA, USA and Department of Biological Engineering, MIT, Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-8851-1224
M NohDepartment of Mechanical Engineering, MIT, Cambridge, MA, USA. soenksen@mit.edu and Research Laboratory of Electronics, MIT, Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-5876-8854
L G GriffithDepartment of Mechanical Engineering, MIT, Cambridge, MA, USA. soenksen@mit.edu and Department of Biological Engineering, MIT, Cambridge, MA, USA.
D L TrumperDepartment of Mechanical Engineering, MIT, Cambridge, MA, USA. soenksen@mit.edu and Research Laboratory of Electronics, MIT, Cambridge, MA, USA.

Funding

Perfused 3D Tissue Surrogates for Complex Cell-Cell Communication SystemsR01EB010246 · NIBIB · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GRIFFITH, LINDA G · 2009 to 2013
$3.3M
Microvascular Permeability, Inflammation, and Lesion Physiology in Endometriosis: A Microphysiological Systems ApproachU01EB029132 · NIBIB · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GRIFFITH, LINDA G · 2019 to 2023
$2.9M
NIBIB NIH HHS R01 EB010246NIBIB NIH HHS U01 EB029132
6 · The paper itself

Abstract

Precise fluid height sensing in open-channel microfluidics has long been a desirable feature for a wide range of applications. However, performing accurate measurements of the fluid level in small-scale reservoirs (<1 mL) has proven to be an elusive goal, especially if direct fluid-sensor contact needs to be avoided. In particular, gravity-driven systems used in several microfluidic applications to establish pressure gradients and impose flow remain open-loop and largely unmonitored due to these sensing limitations. Here we present an optimized self-shielded coplanar capacitive sensor design and automated control system to provide submillimeter fluid-height resolution (∼250 μm) and control of small-scale open reservoirs without the need for direct fluid contact. Results from testing and validation of our optimized sensor and system also suggest that accurate fluid height information can be used to robustly characterize, calibrate and dynamically control a range of microfluidic systems with complex pumping mechanisms, even in cell culture conditions. Capacitive sensing technology provides a scalable and cost-effective way to enable continuous monitoring and closed-loop feedback control of fluid volumes in small-scale gravity-dominated wells in a variety of microfluidic applications.

Identifiers

PMID29437172
PMCPMC9011357

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.