Evidence map›Paper›PMID 29437119›Full record

Trial reportCirculation2018

Transplant-Free Survival and Interventions at 6 Years in the SVR Trial.

Jane W Newburger, Lynn A Sleeper, J William Gaynor, Danielle Hollenbeck-Pringle, Peter C Frommelt, Jennifer S Li, William T Mahle, Ismee A Williams, Andrew M Atz, Kristin M Burns and 13 more

Registry-linked trialAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Circulation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00115934 (Trial of Right Ventricular Versus Modified Blalock-Taussig Shunt in Infants With Single Ventricle Defect Undergoing Staged Reconstruction), which is not on this map. Cited by 91 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
91citing papers in PubMed, 4 pooled it
16.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00115934 nacompletednot on this map

Trial of Right Ventricular Versus Modified Blalock-Taussig Shunt in Infants With Single Ventricle Defect Undergoing Staged Reconstruction (A Trial Conducted by the Pediatric Heart Network)

TypeinterventionalSponsorCarelon ResearchRan2005 to 2009Enrolled555ConditionsHeart Defects, CongenitalArmsBlalock-Taussig pulmonary artery shunt, Right ventricular to pulmonary artery shunt
3 · Its place in the literature

Who cites it

91 citing papers in PubMed, 4 syntheses or guidelines pooled it, 243 citations in OpenAlex.

  1. Pooled it
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  11. Article
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  14. Is There a Unified Etiology of Hypoplastic Left Heart Syndrome? Evaluating Genetic, Structural, and Hemodynamic Models of Disease Initiation.Pathophysiology : the official journal of the International Society for Pathophysiology · 2026
    Review
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  16. Observational
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31 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

23 authors at 1 institution in 1 country.

Jane W NewburgerBoston Children's Hospital and Harvard Medical School, MA (J.W.N., L.A.S., C.D.-M.). jane.newburger@cardio.chboston.org.
Lynn A SleeperBoston Children's Hospital and Harvard Medical School, MA (J.W.N., L.A.S., C.D.-M.).
J William GaynorChildren's Hospital of Philadelphia and University of Pennsylvania Medical School, Philadelphia (J.W.G.).
Danielle Hollenbeck-PringleNew England Research Institutes, Watertown, MA (D.H.-P., S.C., P.S.).
Peter C FrommeltChildren's Hospital of Wisconsin and Medical College of Wisconsin, Milwaukee (P.C.F., N.S.G.).
Jennifer S LiNorth Carolina Consortium, Duke University, Durham (J.S.L.).
William T MahleChildren's Healthcare of Atlanta and Emory University, GA (W.T.M.).
Ismee A WilliamsMorgan Stanley Children's Hospital of New York-Presbyterian, Columbia College of Physicians and Surgeons, NY (I.A.W.).
Andrew M AtzMedical University of South Carolina, Charleston (A.M.A.).
Kristin M BurnsNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD (KM.B.).
Shan ChenNew England Research Institutes, Watertown, MA (D.H.-P., S.C., P.S.).
James CnotaCincinnati Children's Medical Center, OH (J.C.).
Carolyn Dunbar-MastersonBoston Children's Hospital and Harvard Medical School, MA (J.W.N., L.A.S., C.D.-M.).
Nancy S GhanayemChildren's Hospital of Wisconsin and Medical College of Wisconsin, Milwaukee (P.C.F., N.S.G.).
Caren S GoldbergUniversity of Michigan Medical School, Ann Arbor (C.S.G., R.G.O.).
Jeffrey P JacobsCongenital Heart Institute of Florida, St. Petersburg (J.P.J.).
Alan B LewisChildren's Hospital Los Angeles, CA (A.B.L.).
Seema MitalHospital for Sick Children, Toronto, Ontario, Canada (S.M.).
Christian PizarroNemours Cardiac Center, Wilmington, DE (C.P.).
Aaron EckhauserPrimary Children's Hospital and the University of Utah, Salt Lake City (A.E.).
Paul StarkNew England Research Institutes, Watertown, MA (D.H.-P., S.C., P.S.).
Richard G OhyeUniversity of Michigan Medical School, Ann Arbor (C.S.G., R.G.O.).
Pediatric Heart Network Investigators
Medical University of South Carolina · US

Funding

Pediatric Heart network DCCU10HL068270 · NHLBI · NEW ENGLAND RESEARCH INSTITUTES, INC. · PI MILLER, JULIE ELAINE, TRACHTENBERG, FELICIA LYNN · 2011 to 2016
$44.9M
Ventricular Volumes and Varability (VVV)U01HL068270 · NHLBI · NEW ENGLAND RESEARCH INSTITUTES, INC. · PI SLEEPER, LYNN A · 2001 to 2010
$40.3M
Pediatric Heart Network: Follow-up of the Single Ventricle Reconstruction TrialU01HL068290 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LAI, WYMAN W · 2001 to 2010
$4.1M
Pediatric Heart Disease Network: CHOP MembershipU01HL068279 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI VETTER, VICTORIA L · 2001 to 2010
$3.7M
Randomized Therapeutic Trials in Pediatric Heart DiseaseU01HL068285 · NHLBI · CHILDREN'S HOSPITAL BOSTON · PI NEWBURGER, JANE W. · 2001 to 2010
$3.4M
Randomized Clinical Trials for Pediatric Heart DiseaseU01HL068281 · NHLBI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI SAUL, J PHILIP · 2001 to 2010
$3.2M
Clinical and genomic responses to remote ischemic preconditioningU01HL068288 · NHLBI · HOSPITAL FOR SICK CHLDRN (TORONTO) · PI MCCRINDLE, BRIAN W · 2001 to 2010
$3.0M
Pediatric Heart Network Clinical Research Centers - Boston Children's HospitalUG1HL135685 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI NEWBURGER, JANE W., TRIEDMAN, JOHN K · 2017 to 2023
$2.7M
Intermountain Pediatric Heart Disease Research CenterU01HL068292 · NHLBI · UNIVERSITY OF UTAH · PI MINICH, L. LUANN · 2001 to 2010
$2.7M
The Duke-UNC-CH Pediatric Cardiology Clinical CenterU01HL068269 · NHLBI · DUKE UNIVERSITY · PI LI, JENNIFER S · 2001 to 2010
$2.6M
Pediatric Heart Network Prairieland ConsortiumUG1HL135678 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI CNOTA, JAMES, PAYNE, RONALD MARK · 2017 to 2023
$2.4M
Pediatric Heart Network - Utah CenterUG1HL135646 · NHLBI · UNIVERSITY OF UTAH · PI MINICH, L. LUANN, WILLIAMS, RICHARD VINCENT · 2017 to 2023
$2.3M
NHLBI NIH HHS U01 HL068269NHLBI NIH HHS U01 HL068270NHLBI NIH HHS U01 HL068279NHLBI NIH HHS U01 HL068281NHLBI NIH HHS U01 HL068285NHLBI NIH HHS U01 HL068288NHLBI NIH HHS U01 HL068290NHLBI NIH HHS U01 HL068292NHLBI NIH HHS U01 HL085057NHLBI NIH HHS U10 HL068270NHLBI NIH HHS U10 HL109778NHLBI NIH HHS UG1 HL135646NHLBI NIH HHS UG1 HL135678NHLBI NIH HHS UG1 HL135682NHLBI NIH HHS UG1 HL135685NHLBI NIH HHS UG1 HL135689
6 · The paper itself

Abstract

backgroundIn the SVR trial (Single Ventricle Reconstruction), 1-year transplant-free survival was better for the Norwood procedure with right ventricle-to-pulmonary artery shunt (RVPAS) compared with a modified Blalock-Taussig shunt in patients with hypoplastic left heart and related syndromes. At 6 years, we compared transplant-free survival and other outcomes between the groups.

methodsMedical history was collected annually using medical record review, telephone interviews, and the death index. The cohort included 549 patients randomized and treated in the SVR trial.

resultsTransplant-free survival for the RVPAS versus modified Blalock-Taussig shunt groups did not differ at 6 years (64% versus 59%,

conclusionsBy 6 years, the hazards of death or transplant and catheter interventions were not different between the RVPAS versus modified Blalock-Taussig shunt groups. Children assigned to the RVPAS group had 5% higher transplant-free survival, but the difference did not reach statistical significance, and they required more catheter interventions. Both treatment groups have accrued important complications. CLINICAL

trial registrationURL: https://www.clinicaltrials.gov. Unique identifier: NCT00115934.

Indexed as

Blalock-Taussig ProcedureCardiac CatheterizationChild, PreschoolDisease-Free SurvivalFollow-Up StudiesFontan ProcedureHeart TransplantationHeart VentriclesHumansHypoplastic Left Heart SyndromeInfantInterviews as TopicKaplan-Meier EstimateNorwood ProceduresProportional Hazards ModelsPulmonary Arterycardiac surgerycongenital heart defectcongenital heart diseaseNorwood proceduresingle ventricle

Identifiers

PMID29437119
PMCPMC5963989
OpenAlexW2803399435

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.