Evidence map›Paper›PMID 29437118›Full record

ArticleCirculation2018

Association Between Early Hyperoxia Exposure After Resuscitation From Cardiac Arrest and Neurological Disability: Prospective Multicenter Protocol-Directed Cohort Study.

Brian W Roberts, J Hope Kilgannon, Benton R Hunter, Michael A Puskarich, Lisa Pierce, Michael Donnino, Marion Leary, Jeffrey A Kline, Alan E Jones, Nathan I Shapiro and 2 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06908408 (Correlation Between the Severity of Metabolic Acidosis in Patients on Admission to the ICU and Platelet Count Trend in the Following Days), which is not on this map. Cited by 93 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
93citing papers in PubMed, 5 pooled it
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06908408 completednot on this mapstarted 2024, after this paper: background citation

Correlation Between the Severity of Metabolic Acidosis in Patients on Admission to the ICU and Platelet Count Trend in the Following Days

TypeobservationalSponsorUniversity Medical Centre LjubljanaRan2024 to 2024Enrolled484ConditionsPlatelet Count Decline in Critically Ill, Metabolic Acidosis, Metabolic Acidosis Severity, Platelet Count Decline in ICU PatientsArmsCorrrelation between metabolic acidosis severity in patients on admission to the ICU and platelet count trend in 2 days following admission was investigated
3 · Its place in the literature

Who cites it

93 citing papers in PubMed, 5 syntheses or guidelines pooled it, 32 citations in OpenAlex.

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  12. A logical interpretation of the data on optimal oxygen therapy targets for unresponsive adults in ICU after cardiac arrest.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2026
    Article
  13. Article
  14. Management of non-Cardiac Organ Failure in cardiogenic shock.American heart journal plus : cardiology research and practice · 2025
    Article
  15. Review
  16. Article
  17. Review
  18. Article
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33 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 1 country.

Brian W RobertsDepartment of Emergency Medicine (B.W.R., J.H.K., S.T.).
J Hope KilgannonDepartment of Emergency Medicine (B.W.R., J.H.K., S.T.).
Benton R HunterDepartment of Emergency Medicine, Indiana University School of Medicine, Indianapolis (B.R.H., J.A.K.).
Michael A PuskarichDepartment of Emergency Medicine, University of Mississippi Medical Center, Jackson (M.A.P., A.E.J.).
Lisa PierceDepartment of Medicine, Division of Critical Care Medicine (L.P., S.T.), Cooper University Hospital and Cooper Medical School of Rowan University, Camden, NJ.
Michael DonninoDepartment of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA (M.D., N.I.S.).
Marion LearyCenter for Resuscitation Science and Department of Emergency Medicine, University of Pennsylvania, Philadelphia (M.L., B.S.A.).
Jeffrey A KlineDepartment of Emergency Medicine, Indiana University School of Medicine, Indianapolis (B.R.H., J.A.K.).
Alan E JonesDepartment of Emergency Medicine, University of Mississippi Medical Center, Jackson (M.A.P., A.E.J.).
Nathan I ShapiroDepartment of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA (M.D., N.I.S.).
Benjamin S AbellaCenter for Resuscitation Science and Department of Emergency Medicine, University of Pennsylvania, Philadelphia (M.L., B.S.A.).
Stephen TrzeciakDepartment of Emergency Medicine (B.W.R., J.H.K., S.T.) trzeciak-stephen@cooperhealth.edu.
Beth Israel Deaconess Medical Center · USIndiana University School of MedicineCooper University Hospital · USJackson Memorial Hospital · USRowan University · USUniversity of Mississippi Medical Center · US

Funding

Tracking and Evaluation CoreU54GM115428 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI LIRETTE, SETH · 2016 to 2025
$38.2M
Neurological and cognitive effects of hyperoxia after cardiac arrestR01HL112815 · NHLBI · COOPER UNIVERSITY HOSPITAL · PI TRZECIAK, STEPHEN WALTER · 2013 to 2016
$2.4M
Postresuscitation PaCO2 and neurological outcome after cardiac arrestK23HL126979 · NHLBI · ROWAN UNIVERSITY · PI ROBERTS, BRIAN W · 2015 to 2019
$769k
NHLBI NIH HHS K23 HL126979NHLBI NIH HHS R01 HL112815NIGMS NIH HHS U54 GM115428
6 · The paper itself

Abstract

backgroundStudies examining the association between hyperoxia exposure after resuscitation from cardiac arrest and clinical outcomes have reported conflicting results. Our objective was to test the hypothesis that early postresuscitation hyperoxia is associated with poor neurological outcome.

methodsThis was a multicenter prospective cohort study. We included adult patients with cardiac arrest who were mechanically ventilated and received targeted temperature management after return of spontaneous circulation. We excluded patients with cardiac arrest caused by trauma or sepsis. Per protocol, partial pressure of arterial oxygen (Pao

resultsOf the 280 patients included, 105 (38%) had exposure to hyperoxia. Poor neurological function at hospital discharge occurred in 70% of patients in the entire cohort and in 77% versus 65% among patients with versus without exposure to hyperoxia respectively (absolute risk difference, 12%; 95% confidence interval, 1-23). Hyperoxia was independently associated with poor neurological function (relative risk, 1.23; 95% confidence interval, 1.11-1.35). On multivariable analysis, a 1-hour-longer duration of hyperoxia exposure was associated with a 3% increase in risk of poor neurological outcome (relative risk, 1.03; 95% confidence interval, 1.02-1.05). We found that the association with poor neurological outcome began at ≥300 mm Hg.

conclusionsEarly hyperoxia exposure after resuscitation from cardiac arrest was independently associated with poor neurological function at hospital discharge.

Indexed as

Cardiopulmonary ResuscitationHyperoxiaAdultAgedCohort StudiesFemaleHeart ArrestHospital MortalityHumansMaleMiddle AgedNervous System DiseasesOxygenPartial PressurePatient DischargeProspective StudiesOxygenbrain injuriesheart arresthyperoxianervous system

Identifiers

PMID29437118
PMCPMC6370332
OpenAlexW2977795338

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.