Evidence map›Paper›PMID 29437116›Full record

SynthesisCirculation2018

Cardiovascular Disease and Breast Cancer: Where These Entities Intersect: A Scientific Statement From the American Heart Association.

Laxmi S Mehta, Karol E Watson, Ana Barac, Theresa M Beckie, Vera Bittner, Salvador Cruz-Flores, Susan Dent, Lavanya Kondapalli, Bonnie Ky, Tochukwu Okwuosa and 3 more

Erratum issued Registry-linked trialOpen access · bronzeAbstract readSystematic Review
In one paragraph

Synthesis in Circulation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT07253987 (Cancer Survivors Program), which is not on this map. Cited by 466 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
466citing papers in PubMed, 12 pooled it
56.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07253987 narecruitingnot on this mapstarted 2025, after this paper: background citation

Cancer Survivors Program: Effectiveness of Monitoring Adverse Events After Completion of Curative Treatment for Breast and Prostate Cancer

TypeinterventionalSponsorMasaryk Memorial Cancer InstituteRan2025 to 2026Enrolled200ConditionsProstate Cancer Patients, Breast Cancer PatientsArmsactive screening of adverse effects of anticancer therapy based on specific questionnaire + quality of life screening
3 · Its place in the literature

Who cites it

466 citing papers in PubMed, 12 syntheses or guidelines pooled it, 803 citations in OpenAlex.

  1. Pooled it
  2. Guideline
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  4. Pooled it
  5. Statins and prognosis of female breast cancer: a meta-analysis.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025
    Pooled it
  6. Impact of exercise-based prehabilitation on cardiometabolic health in surgical patients with cancer: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Pooled it
  7. Pooled it
  8. Pooled it
  9. Combined lifestyle factors on mortality and cardiovascular disease among cancer survivors: a systematic review and meta-analysis of cohort studies.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Pooled it
  10. Brazilian Guideline on Menopausal Cardiovascular Health - 2024.Arquivos brasileiros de cardiologia · 2024
    Guideline
  11. Beta-blocker use and breast cancer outcomes: a meta-analysis.Breast cancer research and treatment · 2024
    Pooled it
  12. Pooled it
  13. Trial
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article

406 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 4 countries.

Laxmi S Mehta
Karol E Watson
Ana Barac
Theresa M Beckie
Vera Bittner
Salvador Cruz-Flores
Susan Dent
Lavanya Kondapalli
Bonnie Ky
Tochukwu Okwuosa
Ileana L Piña
Annabelle Santos Volgman
American Heart Association Cardiovascular Disease in Women and Special Populations Committee of the Council on Clinical Cardiology; Council on Cardiovascular and Stroke Nursing; and Council on Quality of Care and Outcomes Research
A.S. Watson (Netherlands) · NLdataPartner (Czechia) · CZDentsply Sirona (United States) · USMaharani Laxmi Bai Medical College · IN

Funding

Multimarker Risk Prediction in Cancer Therapy CardiotoxicityR01HL118018 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI KY, BONNIE · 2014 to 2018
$3.7M
Markers of Oxidative and Nitrosative Stress in Anthracycline Cardiotoxicity and Statin CardioprotectionR21HL141802 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI KY, BONNIE · 2018 to 2019
$469k
NHLBI NIH HHS R01 HL118018NHLBI NIH HHS R21 HL141802
6 · The paper itself

Abstract

Cardiovascular disease (CVD) remains the leading cause of mortality in women, yet many people perceive breast cancer to be the number one threat to women's health. CVD and breast cancer have several overlapping risk factors, such as obesity and smoking. Additionally, current breast cancer treatments can have a negative impact on cardiovascular health (eg, left ventricular dysfunction, accelerated CVD), and for women with pre-existing CVD, this might influence cancer treatment decisions by both the patient and the provider. Improvements in early detection and treatment of breast cancer have led to an increasing number of breast cancer survivors who are at risk of long-term cardiac complications from cancer treatments. For older women, CVD poses a greater mortality threat than breast cancer itself. This is the first scientific statement from the American Heart Association on CVD and breast cancer. This document will provide a comprehensive overview of the prevalence of these diseases, shared risk factors, the cardiotoxic effects of therapy, and the prevention and treatment of CVD in breast cancer patients.

Indexed as

Breast NeoplasmsCardiovascular DiseasesAge FactorsCancer SurvivorsDecision MakingFemaleHumansObesityRisk FactorsSmokingAHA Scientific Statementbreast cancercardiotoxicitycardiovascular diseaseoncologypreventionrisk factors

Identifiers

PMID29437116
PMCPMC6722327
OpenAlexW2791340070

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.