Evidence map›Paper›PMID 29436917›Full record

ArticleInterventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences2018

Improved procedural safety following protocol changes for selective ophthalmic arterial infusion of chemotherapy for treatment of ocular retinoblastoma.

Simon Ammanuel, Matthew D Alexander, Bertil Damato, Daniel L Cooke, Van V Halbach, Matthew R Amans, Christopher F Dowd, Randall T Higashida, Steven W Hetts

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
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  3. Comparison of single- versus multi-drug treatment for intra-arterial chemotherapy (IAC) in children with retinoblastoma.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Simon Ammanuel1 Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA.
Matthew D Alexander2 Department of Radiology and Imaging Sciences, University of Utah, Salt Lake City, UT, USA.
Bertil Damato3 Department of Ophthalmology, University of California San Francisco, San Francisco, CA, USA.
Daniel L Cooke1 Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA.
Van V Halbach1 Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA.
Matthew R Amans1 Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA.
Christopher F Dowd1 Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA.
Randall T Higashida1 Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA.
Steven W Hetts1 Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-5885-7259
University of California, San Francisco · USUniversity of Utah · US

Funding

Endovascular Chemofiltration: Optimizing Removal of Chemotherapeutics and Nanoparticles from the Blood to Reduce ToxicityR01CA194533 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HETTS, STEVEN WILLIAM · 2015 to 2019
$2.6M
NCI NIH HHS R01 CA194533
6 · The paper itself

Abstract

Purpose The aim was to evaluate the impact of protocol changes in selective ophthalmic arterial infusion (SOAI) for treatment of retinoblastoma (Rb). Methods A retrospective review was completed of 35 patients with Rb who were treated with SOAI between March 2010 and January 2017. Treatment details were tabulated for each SOAI session. SOAI protocol was changed in June 2015, and differences before and after this change were evaluated using two-tail chi-square tests and independent sample t-tests to note any differences in technical complications, need for enucleation, and other outcome variables Results 125 SOAI sessions occurred. No technical complications occurred during the study. Two complications (1.6%) occurred in the postoperative setting. Both complications occurred prior to the change in protocol. Comparing the complication rates between the two protocols showed no significant difference (2.2% versus 0.0%; p = 0.505); 29 of 43 (67.4%) eyes had their vision preserved overall. Conclusions SOAI is an effective treatment for Rb. The refined protocol described herein was associated with fewer complications.

Indexed as

Clinical ProtocolsOphthalmic ArteryAngiographyAntineoplastic AgentsFemaleHumansInfusions, Intra-ArterialMaleRetinal NeoplasmsRetinoblastomaRetrospective StudiesTreatment OutcomeAntineoplastic AgentsInterventional neurooncologyintra-arterial chemotherapyretinoblastoma

Identifiers

PMID29436917
PMCPMC5967188
OpenAlexW2792457078

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.