Evidence map›Paper›PMID 29436740›Full record

Trial reportMovement disorders : official journal of the Movement Disorder Society2018

Multitarget transcranial direct current stimulation for freezing of gait in Parkinson's disease.

Moria Dagan, Talia Herman, Rachel Harrison, Junhong Zhou, Nir Giladi, Giulio Ruffini, Brad Manor, Jeffrey M Hausdorff

Registry-linked trialAbstract readRandomized Controlled TrialVideo-Audio Media
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Movement disorders : official journal of the Movement Disorder Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05264909 (Assessment of Transcranial Electrical Stimulation and Auditory Stimulation During Walking in Parkinson Patients), which is not on this map. Cited by 77 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
77citing papers in PubMed, 11 pooled it
7.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05264909 naunknown statusnot on this mapstarted 2021, after this paper: background citation

Assessment of Transcranial Electrical Stimulation and Auditory Stimulation During Walking in Parkinson Patients

TypeinterventionalSponsorCorporación de Rehabilitación Club de Leones Cruz del SurRan2021 to 2022Enrolled5ConditionsParkinson DiseaseArmsMulti-channel Transcranial direct current stimulation
3 · Its place in the literature

Who cites it

77 citing papers in PubMed, 11 syntheses or guidelines pooled it, 152 citations in OpenAlex.

  1. TMS and tDCS as potential tools for the treatment of cognitive deficits in Parkinson's disease: a meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
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  16. Linking Invasive and Noninvasive Brain Stimulation in Parkinson's Disease: A Randomized Trial.Movement disorders : official journal of the Movement Disorder Society · 2024
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17 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Moria DaganCenter for the Study of Movement, Cognition and Mobility, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
Talia HermanCenter for the Study of Movement, Cognition and Mobility, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
Rachel HarrisonInstitute for Aging Research, Hebrew SeniorLife, Harvard Medical School, Boston, Massachusetts, USA.
Junhong ZhouInstitute for Aging Research, Hebrew SeniorLife, Harvard Medical School, Boston, Massachusetts, USA.
Nir GiladiCenter for the Study of Movement, Cognition and Mobility, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
Giulio RuffiniNeuroelectrics Corporation, Cambridge, Massachusetts, USA.
Brad ManorInstitute for Aging Research, Hebrew SeniorLife, Harvard Medical School, Boston, Massachusetts, USA.
Jeffrey M HausdorffCenter for the Study of Movement, Cognition and Mobility, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
Hebrew SeniorLife · USTel Aviv University · ILHarvard University · USRush University Medical Center · USTel Aviv Sourasky Medical Center · IL

Funding

TUFTS--FIELDINGP30AG031679 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI SHALENDER BHASIN · 2008 to 2026
$23.9M
NIA NIH HHS P30 AG031679
6 · The paper itself

Abstract

backgroundRecent findings suggest that transcranial direct current stimulation of the primary motor cortex may ameliorate freezing of gait. However, the effects of multitarget simultaneous stimulation of motor and cognitive networks are mostly unknown. The objective of this study was to evaluate the effects of multitarget transcranial direct current stimulation of the primary motor cortex and left dorsolateral prefrontal cortex on freezing of gait and related outcomes.

methodsTwenty patients with Parkinson's disease and freezing of gait received 20 minutes of transcranial direct current stimulation on 3 separate visits. Transcranial direct current stimulation targeted the primary motor cortex and left dorsolateral prefrontal cortex simultaneously, primary motor cortex only, or sham stimulation (order randomized and double-blinded assessments). Participants completed a freezing of gait-provoking test, the Timed Up and Go, and the Stroop test before and after each transcranial direct current stimulation session.

resultsPerformance on the freezing of gait-provoking test (P = 0.010), Timed Up and Go (P = 0.006), and the Stroop test (P = 0.016) improved after simultaneous stimulation of the primary motor cortex and left dorsolateral prefrontal cortex, but not after primary motor cortex only or sham stimulation.

conclusionsTranscranial direct current stimulation designed to simultaneously target motor and cognitive regions apparently induces immediate aftereffects in the brain that translate into reduced freezing of gait and improvements in executive function and mobility. © 2018 International Parkinson and Movement Disorder Society.

Indexed as

AgedCohort StudiesDouble-Blind MethodFemaleFreezing Reaction, CatalepticGait Disorders, NeurologicHumansMaleMiddle AgedMotor CortexParkinson DiseasePrefrontal CortexStroop TestTranscranial Direct Current StimulationTreatment Outcomebrain stimulationfreezing of gaitParkinson's diseasetranscranial direct current stimulation

Identifiers

PMID29436740
PMCPMC5964604
OpenAlexW2793657920

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.