ArticleExperimental physiology2018
Psychological stress-induced cerebrovascular dysfunction: the role of metabolic syndrome and exercise.
Article in Experimental physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 37 citations in OpenAlex.
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- Mid-life exposure to chronic stress accelerates cerebrovascular dysfunction and upregulates oxidative stress in Alzheimer's disease mice.Journal of Alzheimer's disease : JAD · 2025Article
- The association of eight-year trajectories in total, cognitive-affective, and somatic depressive symptoms with incident stroke: a 10-year follow-up study using HRS and ELSA cohorts.Frontiers in aging neuroscience · 2025Article
- Exposure to Artificial Light at Night Alters Ultradian Rhythms in Endothelial Function.Journal of vascular research · 2025Article
- Qualitative study on health self-management of patients with metabolic syndrome among bereaved population after earthquake.Scientific reports · 2024Article
- Thromboxane-induced cerebral microvascular rarefaction predicts depressive symptom emergence in metabolic disease.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Article
- Xanthine oxidase mediates chronic stress-induced cerebrovascular dysfunction and cognitive impairment.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023Article
- Induced Inflammatory and Oxidative Markers in Cerebral Microvasculature by Mentally Depressive Stress.Mediators of inflammation · 2023Article
- Spouse bereavement and brain pathologies: A propensity score matching study.Psychiatry and clinical neurosciences · 2022Article
- Short-term effects of electronic cigarettes on cerebrovascular function: A time course study.Experimental physiology · 2022Article
- Multimodal Therapeutic Approach in Women with High Risk of Metabolic Syndrome-A Single Group One Center Pre-Post Study.Journal of clinical medicine · 2021Article
- Chronic stress induced perivascular adipose tissue impairment of aortic function and the therapeutic effect of exercise.Experimental physiology · 2021Article
- Low-Intensity Exercise as a Modifier of Depressive Symptoms and Self-Perceived Stress Level in Women with Metabolic Syndrome.Journal of sports science & medicine · 2021Article
- Analysis of cerebrovascular dysfunction caused by chronic social defeat in mice.Brain, behavior, and immunity · 2020Article
- Novel Insight into Neuroimmune Regulatory Mechanisms and Biomarkers Linking Major Depression and Vascular Diseases: The Dilemma Continues.International journal of molecular sciences · 2020Review
- Cerebrovascular dysfunction with stress and depression.Brain circulationReview
- Barrier-environment interactions along the gut-brain axis and their influence on cognition and behaviour throughout the lifespan.Journal of psychiatry & neuroscience : JPNReview
Corrections and comments
- Erratum issuedCorrigendum.2018
Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
Abstract
NEW
findingsWhat is the central question of this study? How does chronic stress impact cerebrovascular function and does metabolic syndrome accelerate the cerebrovascular adaptations to stress? What role does exercise training have in preventing cerebrovascular changes to stress and metabolic syndrome? What is the main finding and its importance? Stressful conditions lead to pathological adaptations of the cerebrovasculature via an oxidative nitric oxide pathway, and the presence of metabolic syndrome produces a greater susceptibility to stress-induced cerebrovascular dysfunction. The results also provide insight into the mechanisms that may contribute to the influence of stress and the role of exercise in preventing the negative actions of stress on cerebrovascular function and structure. ABSTRACT: Chronic unresolvable stress leads to the development of depression and cardiovascular disease. There is a high prevalence of depression with the metabolic syndrome (MetS), but to what extent the MetS concurrent with psychological stress affects cerebrovascular function is unknown. We investigated the differential effect of MetS on cerebrovascular structure/function in rats (16-17 weeks old) following 8 weeks of unpredictable chronic mild stress (UCMS) and whether exercise training could limit any cerebrovascular dysfunction. In healthy lean Zucker rats (LZR), UCMS decreased (28%, P < 0.05) ex vivo middle cerebral artery (MCA) endothelium-dependent dilatation (EDD), but changes in MCA remodelling and stiffness were not evident, though cerebral microvessel density (MVD) decreased (30%, P < 0.05). The presence of UCMS and MetS (obese Zucker rats; OZR) decreased MCA EDD (35%, P < 0.05) and dilatation to sodium nitroprusside (20%, P < 0.05), while MCA stiffness increased and cerebral MVD decreased (31%, P < 0.05), which were linked to reduced nitric oxide and increased oxidative levels. Aerobic exercise prevented UCMS impairments in MCA function and MVD in LZR, and partly restored MCA function, stiffness and MVD in OZR. Our data suggest that the benefits of exercise with UCMS were due to a reduction in oxidative stress and increased production of nitric oxide in the cerebral vessels. In conclusion, UCMS significantly impaired MCA structure and function, but the effects of UCMS were more substantial in OZR vs. LZR. Importantly, aerobic exercise when combined with UCMS prevented the MCA dysfunction through subtle shifts in nitric oxide and oxidative stress in the cerebral microvasculature.
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