ArticleJournal of clinical microbiology2018
The Slow March toward Rapid Phenotypic Antimicrobial Susceptibility Testing: Are We There Yet?
Article in Journal of clinical microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Computational paradigms for antimicrobial resistance prediction: integrating multi-omics, structural modeling, and foundation artificial intelligence systems.Briefings in bioinformatics · 2026Pooled it
- Rapid versus standard antimicrobial susceptibility testing to guide treatment of bloodstream infection.The Cochrane database of systematic reviews · 2021Pooled it
- Advancing antimicrobial therapy: evaluating the ASTar (Q-linea) System for rapid AST in Gram-negative bloodstream infections.Microbiology spectrum · 2026Article
- Single-center clinical laboratory evaluation of VITEK REVEAL for rapid phenotypic antimicrobial susceptibility testing of Gram-negative organisms directly from positive blood cultures.Frontiers in microbiology · 2026Article
- Rapid detection of carbapenem resistance via MALDI-TOF MS using an innovative broth microgrowth assay.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2025Article
- Evaluation of a Novel Rapid Phenotypic Antimicrobial Susceptibility Testing System.Antibiotics (Basel, Switzerland) · 2025Article
- Multi-center evaluation of the Selux next-generation phenotyping system for gram-negative direct-from-positive blood culture antimicrobial susceptibility testing.Journal of clinical microbiology · 2025Article
- Performance of the LifeScale automated rapid phenotypic antimicrobial susceptibility testing on Gram-negative rods directly from positive blood cultures.Journal of clinical microbiology · 2024Article
- Multicenter evaluation of the Selux Next-Generation Phenotyping antimicrobial susceptibility testing system.Journal of clinical microbiology · 2024Article
- Rapid Mycobacterium abscessus antimicrobial susceptibility testing based on antibiotic treatment response mapping via Raman Microspectroscopy.Annals of clinical microbiology and antimicrobials · 2023Article
- Comparison of genotypic and phenotypic antimicrobial profile in carbapenemases producing Klebsiella pneumoniae.Acta bio-medica : Atenei Parmensis · 2023Article
- Antimicrobial susceptibility testing for Gram positive cocci towards vancomycin using scanning electron microscopy.Current research in microbial sciences · 2022Article
- Article
- Detection of Cephalosporin and Fluoroquinolone Resistance Genes via Novel Multiplex qPCR in FecalFrontiers in microbiology · 2021Article
- Rapid identification and antimicrobial susceptibility testing of Gram-negative rod on positive blood cultures using MicroScan panels.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2021Article
- A Rapid Antimicrobial Susceptibility Test forInfection and drug resistance · 2021Article
- EUCAST rapid antimicrobial susceptibility testing (RAST) in blood cultures: validation in 55 European laboratories.The Journal of antimicrobial chemotherapy · 2020Article
- Cantilever Sensors for Rapid Optical Antimicrobial Sensitivity Testing.ACS sensors · 2020Article
- Time to Result for Pathogen Identification and Antimicrobial Susceptibility Testing of Bronchoalveolar Lavage and Endotracheal Aspirate Specimens in U.S. Acute Care Hospitals.Journal of clinical microbiology · 2020Article
- Clinical impact of rapid susceptibility testing on Mueller-Hinton Rapid-SIR directly from urine specimens.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2020Article
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1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antimicrobial susceptibility testing (AST) provides critical information for the management of patients with infections. The gold standard methods for assessing organism susceptibility are still based on growth and require incubation over relatively long periods of time. Until now, little progress has been made in developing rapid, growth-based, phenotypic AST systems. This commentary puts the recently FDA-cleared Accelerate PhenoTest (P. Pancholi et al., J Clin Microbiol 56:e01329-17, 2018, https://doi.org/10.1128/JCM.01329-17) in context by providing a historical perspective on attempts to accelerate phenotypic susceptibility results. In addition, some promising new innovations that promise to shorten the turnaround time for phenotypic AST will be briefly reviewed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.