ReviewEuropean respiratory review : an official journal of the European Respiratory Society2018
Neutrophil to lymphocyte ratio and clinical outcomes in COPD: recent evidence and future perspectives.
Review in European respiratory review : an official journal of the European Respiratory Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04923360 (Morphological Parameters of Blood Cell's Activation in Characterization and Prognosis in a COPD Patients Cohort), which is not on this map. Cited by 113 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Morphological Parameters of Blood Cell's Activation in Characterization and Prognosis in a COPD Patients Cohort
Who cites it
113 citing papers in PubMed, 6 syntheses or guidelines pooled it, 220 citations in OpenAlex.
- Predictive value of neutrophil to lymphocyte ratio for the clinical outcomes of acquired immune deficiency syndrome: a systematic review and meta-analysis.Frontiers in medicine · 2025Pooled it
- The Association between Neutrophil-to-Lymphocyte Ratio and Glycemic Control in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis.Journal of diabetes research · 2023Pooled it
- Predictive values of neutrophil-to-lymphocyte ratio on disease severity and mortality in COVID-19 patients: a systematic review and meta-analysis.Critical care (London, England) · 2020Pooled it
- Association between the neutrophil-to-lymphocyte ratio and obstructive sleep apnea: a meta-analysis.Scientific reports · 2020Pooled it
- Associations between the neutrophil-to-lymphocyte and the platelet-to-lymphocyte ratios and the presence and severity of psoriasis: a systematic review and meta-analysis.Clinical and experimental medicine · 2019Pooled it
- Red blood cell distribution width in pregnancy: a systematic review.Biochemia medica · 2018Pooled it
- Peripheral Blood Neutrophil-Monocyte-to-Lymphocyte Ratio and Long-Term All-Cause Mortality in Patients with Chronic Obstructive Pulmonary Disease: A Population-Based Primary Care Cohort Study.Healthcare (Basel, Switzerland) · 2026Article
- Neutrophil-to-lymphocyte ratio is associated with 30-day mortality in acute pulmonary embolism across European Society of Cardiology risk categories.Research and practice in thrombosis and haemostasis · 2026Article
- Clinical Characteristics and Health Care Resource Utilization Among Individuals Undergoing Alpha-1 Antitrypsin Testing in a Quaternary Health System.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2026Article
- Relationship between the advanced lung cancer inflammation index (ALI) and all-cause and cause-specific mortality among patients with chronic obstructive pulmonary disease (COPD): a population-based study.BMC pulmonary medicine · 2026Article
- One Index Does Not Predict All-Hematological Derived Indices Have Different Predictive Value for ICU Mortality in Critically Ill Patients with Non-Infectious Versus Infectious Acute Exacerbation of COPD.Medicina (Kaunas, Lithuania) · 2026Observational
- Clinical Features and Predictive Risk Factors for Prognosis in Invasive Pulmonary Aspergillosis and Pulmonary Mucormycosis.The clinical respiratory journal · 2026Article
- Blood cell ratio biomarkers of systemic inflammation in chronic obstructive pulmonary disease.Respiratory research · 2026Article
- Validation of the Neutrophil-Lymphocyte Ratio as a Mortality Risk Stratification Marker in Patients with Proximal Femoral Fractures.Biomedicines · 2026Article
- Association between cardiovascular-kidney-metabolic syndrome and chronic obstructive pulmonary disease: a cross-national analysis from global, US, and Chinese populations.Respiratory research · 2026Article
- Blood Cell Ratio Biomarkers of Non-type 2 Inflammation in Chronic Obstructive Pulmonary.Research square · 2026Article
- Elevated C-Reactive Protein-Albumin-Lymphocyte Index Is Associated With Reduced Mortality in Chronic Inflammatory Airway Diseases: A Population-Based Observational Study.Mediators of inflammation · 2026Observational
- Development and External Validation of a Machine Learning Model for 90-Day Readmission in Hospitalized Older Patients with AECOPD: A Two-Center Study.International journal of chronic obstructive pulmonary disease · 2026Article
- Observational
- Multimodal machine learning predicts type 2 respiratory failure in COPD exacerbations: a multicenter XGBoost model with clinical nomogram.Frontiers in medicine · 2026Article
53 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic obstructive pulmonary disease (COPD) is a disabling condition that is characterised by poorly reversible airflow limitation and inflammation. Acute exacerbations of COPD are a common cause of hospitalisation and death among COPD patients. Several biochemical markers have been studied as outcome predictors in COPD; however, their measurement often requires significant time and resources. Relatively simple biomarkers of inflammation calculated from routine complete blood count tests, such as the neutrophil to lymphocyte ratio (NLR), might also predict COPD progression and outcomes. This review discusses the available evidence from studies investigating the associations between the NLR, COPD exacerbations and death in this patient group.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.