ArticleInjury prevention : journal of the International Society for Child and Adolescent Injury Prevention2019
Impacts of an opioid overdose prevention intervention delivered subsequent to acute care.
Article in Injury prevention : journal of the International Society for Child and Adolescent Injury Prevention, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- The Emergency Department as an Opportunity for Naloxone Distribution.The western journal of emergency medicine · 2018Pooled it
- A Rapid Review of the Impact of Systems-Level Policies and Interventions on Population-Level Outcomes Related to the Opioid Epidemic, United States and Canada, 2014-2018.Public health reports (Washington, D.C. : 1974)Pooled it
- Collaborative care intervention for risky opioid use among primary care patients: The STOP randomized clinical trial.Addiction (Abingdon, England) · 2026Trial
- Effect of a peer-led emergency department behavioral intervention on non-fatal opioid overdose: 18-month outcome in the Navigator randomized controlled trial.Addiction (Abingdon, England) · 2024Trial
- The Emergency Department Longitudinal Integrated Care (ED-LINC) intervention targeting opioid use disorder: A pilot randomized clinical trial.Journal of substance abuse treatment · 2022Trial
- A scoping review of emergency department take-home naloxone on patient and health outcomes.CJEM · 2026Article
- Clinical Decision Support to Increase Naloxone Co-prescribing from the Inpatient Setting.Journal of general internal medicine · 2026Observational
- The role of prescribed opioids in Norwegian overdose deaths in 2005-2021.European journal of clinical pharmacology · 2025Article
- Association of Pharmacologic and Nonpharmacologic Management of Acute Low Back Pain with Overdose Hospitalizations: A Nested Case-Control Study.Journal of integrative and complementary medicine · 2025Article
- Article
- Trends in recurrent overdose and treatment initiation following emergency department visits for opioid overdose between 2016 and 2021.Drug and alcohol dependence · 2024Article
- Naloxone distribution programs in the emergency department: A scoping review of the literature.Journal of the American College of Emergency Physicians open · 2024Article
- Behavioural mental health interventions delivered in the emergency department for suicide, overdose and psychosis: a scoping review.BMJ open · 2024Article
- Community-Based Medications First for Opioid Use Disorder - Care Utilization and Mortality Outcomes.Substance abuse and rehabilitation · 2024Article
- Subthreshold opioid use disorder prevention (STOP) trial: a cluster randomized clinical trial: study design and methods.Addiction science & clinical practice · 2023Article
- Study protocol for a multisite randomized controlled trial of a peer navigator intervention for emergency department patients with nonfatal opioid overdose.Contemporary clinical trials · 2023Article
- Harm reduction strategies in acute care for people who use alcohol and/or drugs: A scoping review.PloS one · 2023Article
- Predictors of having naloxone in urban and rural Oregon findings from NHBS and the OR-HOPE study.Drug and alcohol dependence · 2021Article
- Validation of the Opioid Overdose Risk Behavior Scale, version 2 (ORBS-2).Drug and alcohol dependence · 2021Article
- A qualitative study of emergency department patients who survived an opioid overdose: Perspectives on treatment and unmet needs.Academic emergency medicine : official journal of the Society for Academic Emergency Medicine · 2021Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundOpioid overdose is a major and increasing cause of injury and death. There is an urgent need for interventions to reduce overdose events among high-risk persons.
methodsAdults at elevated risk for opioid overdose involving heroin or pharmaceutical opioids who had been cared for in an emergency department (ED) were randomised to overdose education combined with a brief behavioural intervention and take-home naloxone or usual care. Outcomes included: (1) time to first opioid overdose-related event resulting in medical attention or death using competing risks survival analysis; and (2) ED visit and hospitalisation rates, using negative binomial regression and adjusting for time at risk.
resultsDuring the follow-up period, 24% of the 241 participants had at least one overdose event, 85% had one or more ED visits and 55% had at least one hospitalisation, with no significant differences between intervention and comparison groups. The instantaneous risk of an overdose event was not significantly lower for the intervention group (sub-HR: 0.83; 95% CI 0.49 to 1.40). DISCUSSION: These null findings may be due in part to the severity of the population in terms of housing insecurity (70% impermanently housed), drug use, unemployment and acute healthcare issues. Given the high overdose and healthcare utilisation rates, more intensive interventions, such as direct referral and provision of housing and opioid agonist treatment medications, may be necessary to have a substantial impact on opioid overdoses for this high-acuity population in acute care settings. TRIAL REGISTRATION NUMBER: NCT0178830; Results.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.