Evidence map›Paper›PMID 29436203›Full record

ArticleYonsei medical journal2018

Development of a Gustatory Function Test for Clinical Application in Korean Subjects.

Chi Sang Hwang, Jin Won Kim, Salma Saud Al Sharhan, Jin Woong Kim, Hyung Ju Cho, Joo Heon Yoon, Chang Hoon Kim

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Yonsei medical journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04448821 (A Clinical Trial to Evaluate the Effect of Nilotinib on the Pharmacokinetics and Pharmacodynamics of Metformin in Healthy Male Adults), which is not on this map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.9field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04448821 phase1completednot on this mapstarted 2020, after this paper: background citation

A Clinical Trial to Evaluate the Effect of Nilotinib on the Pharmacokinetics and Pharmacodynamics of Metformin in Healthy Male Adults

TypeinterventionalSponsorHyewon ChungRan2020 to 2020Enrolled16ConditionsHealthyArmsMetformin, Metformin + Nilotinib
3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
  2. Article
  3. Prevalence and Associated Factors of Olfactory and Gustatory Loss in Patients With Nasal Septal Deviation.Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. [The application of waterless empirical taste test(WETTLin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2023
    Article
  10. [Reliability of whole-mouth taste test in assessment of gustatory function in healthy adults].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2021
    Article
  11. Prospective assessment of gustatory function after radiotherapy for head and neck cancers.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2020
    Article
  12. Article
  13. Observational
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Chi Sang Hwang *Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0001-7161-7276
Jin Won Kim *Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0002-0085-0326
Salma Saud Al SharhanDepartment of Otorhinolaryngology, Imam Abdulrahman Bin Faisal University and King Fahd Hospital, Al-Khobar, Saudi Arabia.
Jin Woong KimDepartment of Otorhinolaryngology, Imam Abdulrahman Bin Faisal University and King Fahd Hospital, Al-Khobar, Saudi Arabia.
Hyung Ju ChoDepartment of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, Korea.
Joo Heon YoonDepartment of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, Korea.
Chang Hoon KimDepartment of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0003-1238-6396
Yonsei University · KRKing Fahd Hospital of the University · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo obtain validated clinical values suitable for developing a gustatory function test, including umami taste, in a Korean population. MATERIALS AND

methodsThe investigation involved 297 participants with self-reported normal sense of taste and smell. Liquid solutions were used for the assessment of gustatory function. The test consisted of 30 taste solutions [six concentrations of five tastants (sweet, bitter, salty, sour, and umami)]. For evaluation of overall gustatory function, the number of detected or correctly recognized taste thresholds was combined to form a "taste score."

resultsMean values of each detection and recognition threshold for the five tastes in men were consistently lower than those of women. The 10th percentile of taste score for recognition was used as the cut-off value for distinguishing normogeusia from hypogeusia. In subgroup analysis, total taste score from recognition thresholds revealed a significant negative correlation with age, indicating lower scores for increasing age. Taste score for non-smokers was significantly higher than that of smokers, in terms of detection and recognition of taste sensitivities.

conclusionThis gustatory function test was easy to perform, affordable, and time-saving, with the capacity to self-produce and obtain reliable data. Gustatory function was more sensitive in young people, women, and non-smokers.

Indexed as

AdolescentAdultAgedAged, 80 and overChildFemaleHumansLinear ModelsMaleMiddle AgedRepublic of KoreaTasteTaste ThresholdYoung AdultgustationTasteumamivalidated clinical value

Identifiers

PMID29436203
PMCPMC5823837
OpenAlexW2786500876

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.