Evidence map›Paper›PMID 29436054›Full record

ArticleHuman brain mapping2018

Sensorimotor network alterations in children and youth with prenatal alcohol exposure.

Xiangyu Long, Graham Little, Christian Beaulieu, Catherine Lebel

Open access · greenAbstract read
In one paragraph

Article in Human brain mapping, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
4.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 30 citations in OpenAlex.

  1. Review
  2. Article
  3. Impact of Prenatal Alcohol Exposure on Cerebral Cortex Development.Advances in experimental medicine and biology · 2026
    Review
  4. Article
  5. Article
  6. Article
  7. Spiral drawing deficits in children with prenatal alcohol exposure.Alcohol, clinical & experimental research · 2023
    Article
  8. Article
  9. Article
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  14. Article
  15. Review
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  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Xiangyu LongDepartment of Radiology, and Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Alberta, Canada.
Graham LittleDepartment of Biomedical Engineering, University of Alberta, Edmonton, Alberta, Canada.
Christian BeaulieuDepartment of Biomedical Engineering, University of Alberta, Edmonton, Alberta, Canada.
Catherine LebelDepartment of Radiology, and Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Alberta, Canada.ORCID 0000-0002-0344-4032
University of Alberta · CAUniversity of Calgary · CA

Funding

CIHR
6 · The paper itself

Abstract

Children with prenatal alcohol exposure (PAE) often have impaired sensorimotor function. While altered brain structure has been noted in sensorimotor areas, the functional brain alterations remain unclear. This study aims to investigate sensorimotor brain networks in children and youth with PAE using resting-state functional magnetic resonance imaging (rs-fMRI). A parcellation-based network analysis was performed to identify brain networks related to hand/lower limb and face/upper limb function in 59 children and youth with PAE and 50 typically developing controls. Participants with PAE and controls had similar organization of the hand and face areas within the primary sensorimotor cortex, but participants with PAE had altered functional connectivity (FC) between the sensorimotor regions and the rest of the brain. The sensorimotor regions in the PAE group showed less connectivity to certain hubs of the default mode network and more connectivity to areas of the salience network. Overall, our results show that despite similar patterns of organization in the sensorimotor network, subjects with PAE have increased FC between this network and other brain areas, perhaps suggesting overcompensation. These alterations in the sensorimotor network lay the foundation for future studies to evaluate interventions and treatments to improve motor function in children with PAE.

Indexed as

Brain MappingAdolescentAge FactorsChildCorrelation of DataFemaleFetal Alcohol Spectrum DisordersFunctional LateralityHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleNeural PathwaysSensorimotor Cortexfetal alcohol spectrum disordermagnetic resonance imagingneurodevelopmentprenatal alcohol exposureresting-state functional MRIsensorimotor network

Identifiers

PMID29436054
PMCPMC6866525
OpenAlexW2793262619

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.