Evidence map›Paper›PMID 29435815›Full record

ArticleNeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics2018

Nerve Ultrasound Predicts Treatment Response in Chronic Inflammatory Demyelinating Polyradiculoneuropathy-a Prospective Follow-Up.

Florian Härtig, Marlene Ross, Nele Maria Dammeier, Nadin Fedtke, Bianka Heiling, Hubertus Axer, Bernhard F Décard, Eva Auffenberg, Marilin Koch, Tim W Rattay and 5 more

Open access · bronzeAbstract read
In one paragraph

Article in Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 1 pooled it
6.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 1 synthesis or guideline pooled it, 89 citations in OpenAlex.

  1. Pooled it
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  5. Value of 2-Dimensional Shear-Wave Elastography in Assessing Tibial Nerve Stiffness in Diabetic Peripheral Neuropathy.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2026
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  16. [Ultrasound of nerves of the lower extremities].Zeitschrift fur Rheumatologie · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 2 countries.

Florian HärtigDepartment of Neurology, Tübingen University Hospital, University of Tübingen, Hoppe-Seyler-Str. 3, 72076, Tubingen, Germany.
Marlene RossDepartment of Neurology, Tübingen University Hospital, University of Tübingen, Hoppe-Seyler-Str. 3, 72076, Tubingen, Germany.
Nele Maria DammeierDepartment of Neurology, Tübingen University Hospital, University of Tübingen, Hoppe-Seyler-Str. 3, 72076, Tubingen, Germany.
Nadin FedtkeHans Berger Department of Neurology, Jena University Hospital, Jena, 07747, Germany.
Bianka HeilingHans Berger Department of Neurology, Jena University Hospital, Jena, 07747, Germany.
Hubertus AxerHans Berger Department of Neurology, Jena University Hospital, Jena, 07747, Germany.
Bernhard F DécardDepartment of Neurology, Basel University Hospital, Basel, 4031, Switzerland.
Eva AuffenbergDepartment of Neurology, Tübingen University Hospital, University of Tübingen, Hoppe-Seyler-Str. 3, 72076, Tubingen, Germany.
Marilin KochDepartment of Neurology, Tübingen University Hospital, University of Tübingen, Hoppe-Seyler-Str. 3, 72076, Tubingen, Germany.
Tim W RattayDepartment of Neurology, Tübingen University Hospital, University of Tübingen, Hoppe-Seyler-Str. 3, 72076, Tubingen, Germany.
Markus KrumbholzDepartment of Neurology, Tübingen University Hospital, University of Tübingen, Hoppe-Seyler-Str. 3, 72076, Tubingen, Germany.
Antje BornemannInstitute of Brain Research, University of Tübingen, 72076, Tubingen, Germany.
Holger LercheDepartment of Neurology, Tübingen University Hospital, University of Tübingen, Hoppe-Seyler-Str. 3, 72076, Tubingen, Germany.
Natalie WinterDepartment of Neurology, Tübingen University Hospital, University of Tübingen, Hoppe-Seyler-Str. 3, 72076, Tubingen, Germany.
Alexander GrimmDepartment of Neurology, Tübingen University Hospital, University of Tübingen, Hoppe-Seyler-Str. 3, 72076, Tubingen, Germany. alexander.grimm@med.uni-tuebingen.de.
University of Tübingen · DEHertie Institute for Clinical Brain Research · DEJena University Hospital · DEUniversity Hospital of Basel · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As reliable biomarkers of disease activity are lacking, monitoring of therapeutic response in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) remains a challenge. We sought to determine whether nerve ultrasound and electrophysiology scoring could close this gap. In CIDP patients (fulfilling EFNS/PNS criteria), we performed high-resolution nerve ultrasound to determine ultrasound pattern sum scores (UPSS) and predominant echotexture nerve conduction study scores (NCSS) as well as Medical Research Council sum scores (MRCSS) and inflammatory neuropathy cause and treatment disability scores (INCAT) at baseline and after 12 months of standard treatment. We retrospectively correlated ultrasound morphology with nerve histology when available. 72/80 CIDP patients featured multifocal nerve enlargement, and 35/80 were therapy-naïve. At baseline, clinical scores correlated with NCSS (r

Indexed as

UltrasonographyAgedBiomarkersFemaleFollow-Up StudiesHumansMaleMiddle AgedNeural ConductionPolyradiculoneuropathy, Chronic Inflammatory DemyelinatingProspective StudiesSpinal NervesTreatment OutcomeBiomarkersNerve ultrasonography · CIDP · Polyneuropathy · Ultrasound pattern sum score · Nerve ultrasound and therapy.

Identifiers

PMID29435815
PMCPMC5935640
OpenAlexW2792571634

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.