Evidence map›Paper›PMID 29435491›Full record

ArticlemSphere

Genomewide Identification of Essential Genes and Fitness Determinants of

Robert C Shields, Lin Zeng, David J Culp, Robert A Burne

Open access · goldAbstract read
In one paragraph

Article in mSphere. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
9.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 68 citations in OpenAlex.

  1. Specific host translation perturbations promote TnbioRxiv : the preprint server for biology · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. A genome-widebioRxiv : the preprint server for biology · 2026
    Article
  6. Genomic instability and biofilm determinants inbioRxiv : the preprint server for biology · 2026
    Article
  7. Review
  8. Article
  9. Article
  10. Identifying essential genes inJournal of bacteriology · 2025
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Characterization of MreCD inJournal of oral microbiology · 2025
    Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Robert C ShieldsDepartment of Oral Biology, College of Dentistry, University of Florida, Gainesville, Florida, USA.ORCID https://orcid.org/0000-0002-8823-9504
Lin ZengDepartment of Oral Biology, College of Dentistry, University of Florida, Gainesville, Florida, USA.
David J CulpDepartment of Oral Biology, College of Dentistry, University of Florida, Gainesville, Florida, USA.
Robert A BurneDepartment of Oral Biology, College of Dentistry, University of Florida, Gainesville, Florida, USA.ORCID https://orcid.org/0000-0002-4234-0316
University of Florida · US

Funding

GENE REGULATION AND PHYSIOLOGY OF STREPTOCOCCUS MUTANSR01DE012236 · NIDCR · UNIVERSITY OF ROCHESTER · PI Lin Zeng · 1997 to 2026
$8.5M
GENETICS AND PHYSIOLOGY OF ORAL BIOFILMSR01DE013239 · NIDCR · UNIVERSITY OF ROCHESTER · PI BURNE, ROBERT A · 1999 to 2019
$6.6M
Probiotics that moderate pH and antagonize pathogens to promote oral healthR01DE025832 · NIDCR · UNIVERSITY OF FLORIDA · PI BURNE, ROBERT A · 2016 to 2020
$3.4M
NIDCR NIH HHS R01 DE012236NIDCR NIH HHS R01 DE013239NIDCR NIH HHS R01 DE025832
6 · The paper itself

Abstract

Transposon mutagenesis coupled with next-generation DNA sequencing (Tn-seq) is a powerful tool for discovering regions of the genome that are required for the survival of bacteria in different environments. We adapted this technique to the dental caries pathogen

Indexed as

antimicrobial targetsdental cariesessential genomeStreptococcustransposon sequencing

Identifiers

PMID29435491
PMCPMC5806208
OpenAlexW2791562506

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.