ArticleJournal of diabetes research2017
Gut Microbiome and Inflammation: A Study of Diabetic Inflammasome-Knockout Mice.
Article in Journal of diabetes research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 31 citations in OpenAlex.
- The gut microbiota-NLRP3 inflammasome connection: current evidence and perspectives for non-communicable diseases.Molecular and cellular biochemistry · 2025Review
- Lutein augments the hypoglycemic effect of metformin through the gut microbiota-imidazole propionate axis in type 2 diabetic model mice.Scientific reports · 2025Article
- Assessment of ImmobilizedFoods (Basel, Switzerland) · 2024Article
- Serum amyloid A and metabolic disease: evidence for a critical role in chronic inflammatory conditions.Frontiers in cardiovascular medicine · 2023Review
- Characteristics of gut microbiota in representative mice strains: Implications for biological research.Animal models and experimental medicine · 2022Article
- Environmental Factors and the Risk of Developing Type 1 Diabetes-Old Disease and New Data.Biology · 2022Review
- Anti-Diabetic Effects of Ethanol Extract fromFoods (Basel, Switzerland) · 2022Article
- Novel Role of Ghrelin Receptor in Gut Dysbiosis and Experimental Colitis in Aging.International journal of molecular sciences · 2022Article
- The Interaction Between Dietary Fructose and Gut Microbiota in Hyperuricemia and Gout.Frontiers in nutrition · 2022Review
- Article
- Metformin intervention ameliorates AS in ApoE-/- mice through restoring gut dysbiosis and anti-inflammation.PloS one · 2021Article
- Protective Effects of Ghrelin on Fasting-Induced Muscle Atrophy in Aging Mice.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020Article
- Interactions Between Therapeutics for Metabolic Disease, Cardiovascular Risk Factors, and Gut Microbiota.Frontiers in cellular and infection microbiology · 2020Review
- Modulatory Mechanisms of the NLRP3 Inflammasomes in Diabetes.Biomolecules · 2019Review
- Suppression of Glucagon-Like Peptide-1 Release by Inhibition of Intestinal NLRP3 Inflammasome Activation in AscFrontiers in physiology · 2019Article
- Effect of the Chinese Medicine YangZheng XiaoJi on Reducing Fatigue in Mice with Orthotopic Transplantation of Colon Cancer.Evidence-based complementary and alternative medicine : eCAM · 2019Article
- Gut Microbiome in Obesity, Metabolic Syndrome, and Diabetes.Current diabetes reports · 2018Review
- Effects of dietary supplementation withPeerJ · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsDiabetes is a proinflammatory state, evidenced by increased pattern recognition receptors and the inflammasome (NOD-like receptor family pyrin domain (NLRP)) complex. Recent reports have elucidated the role of the gut microbiome in diabetes, but there is limited data on the gut microbiome in NLRP-KO mice and its effect on diabetes-induced inflammation.
methodsGut microbiome composition and biomarkers of inflammation (IL-18, serum amyloid A) were assessed in streptozotocin- (STZ-) induced diabetic mice on a NLRP3-knockout (KO) background versus wild-type diabetic mice.
resultsSAA and IL-18 levels were significantly elevated in diabetic mice (STZ) compared to control (WT) mice, and there was a significant attenuation of inflammation in diabetic NLRP3-KO mice (NLRP3-KO STZ) compared to control mice (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.