Evidence map›Paper›PMID 29435457›Full record

ArticleBioMed research international2017

Tumor Burden and Intraosseous Metabolic Activity as Predictors of Bone Marrow Failure during Radioisotope Therapy in Metastasized Prostate Cancer Patients.

Francesco Fiz, Samine Sahbai, Cristina Campi, Matthias Weissinger, Helmut Dittmann, Cecilia Marini, Michele Piana, Gianmario Sambuceti, Christian la Fougère

Abstract read
In one paragraph

Article in BioMed research international, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
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  7. Metabolic and densitometric correlation between atherosclerotic plaque and trabecular bone: anAmerican journal of nuclear medicine and molecular imaging · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Francesco FizNuclear Medicine Unit, Department of Radiology, University of Tübingen, Tübingen, Germany.ORCID 0000-0003-3932-1330
Samine SahbaiNuclear Medicine Unit, "Henri Mondor" University Hospital, Paris, France.
Cristina CampiNational Council of Research-SPIN, Section of Genoa, Genova, Italy.
Matthias WeissingerNuclear Medicine Unit, Department of Radiology, University of Tübingen, Tübingen, Germany.
Helmut DittmannNuclear Medicine Unit, Department of Radiology, University of Tübingen, Tübingen, Germany.
Cecilia MariniNational Council of Research-IBFM, Section of Genoa, Genova, Italy.
Michele PianaDepartment of Mathematics, University of Genoa, Genova, Italy.
Gianmario SambucetiNuclear Medicine Unit, Department of Health Sciences, University of Genoa, Genova, Italy.ORCID 0000-0003-2979-6500
Christian la FougèreNuclear Medicine Unit, Department of Radiology, University of Tübingen, Tübingen, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

rationaleRadium-223-Dichloride (Ra-223) is an alpha-emitter, used to treat bone metastases. Patients with high metastatic burden and/or with increased trabecular bone uptake could present a higher incidence of hematologic toxicity. We hypothesized that these two factors are predictors of bone marrow failure. MATERIAL AND

methodsA computer algorithm discriminated between trabecular bone (

results

conclusionsIn patients with significant bone tumor burden, degree of bone invasion and trabecular bone uptake are predictors of subsequent bone marrow failure.

Indexed as

AgedAged, 80 and overAnemia, AplasticBlood PlateletsBone MarrowBone Marrow DiseasesBone Marrow Failure DisordersBone NeoplasmsCancellous BoneHemoglobinsHemoglobinuria, ParoxysmalHumansLeukocytesMaleMiddle AgedNeoplasm InvasivenessHemoglobinsRadioisotopesRadiumradium Ra 223 dichloride

Identifiers

PMID29435457
PMCPMC5757096

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.