Evidence map›Paper›PMID 29435345›Full record

ArticleBMJ open respiratory research2017

Differentiation of quantitative CT imaging phenotypes in asthma versus COPD.

Sanghun Choi, Babak Haghighi, Jiwoong Choi, Eric A Hoffman, Alejandro P Comellas, John D Newell, Sally E Wenzel, Mario Castro, Sean B Fain, Nizar N Jarjour and 14 more

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in BMJ open respiratory research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 44 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Observational
  6. Review
  7. Article
  8. Article
  9. Article
  10. A computed tomography imaging-based subject-specific whole-lung deposition model.European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences · 2022
    Article
  11. CT-Based Commercial Software Applications: Improving Patient Care Through Accurate COPD Subtyping.International journal of chronic obstructive pulmonary disease · 2022
    Review
  12. Article
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  14. Article
  15. Article
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  17. Article
  18. Non-eosinophilic asthma: current perspectives.Journal of asthma and allergy · 2018
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

24 authors at 15 institutions in 2 countries.

Sanghun ChoiDepartment of Mechanical Engineering, Kyungpook National University, Daegu, South Korea.
Babak HaghighiDepartment of Mechanical and Industrial Engineering, University of Iowa, Iowa City, Iowa, USA.
Jiwoong ChoiDepartment of Mechanical and Industrial Engineering, University of Iowa, Iowa City, Iowa, USA.
Eric A HoffmanDepartment of Radiology, University of Iowa, Iowa City, Iowa, USA.
Alejandro P ComellasDepartment of Internal Medicine, University of Iowa, Iowa City, Iowa, USA.
John D NewellDepartment of Radiology, University of Iowa, Iowa City, Iowa, USA.
Sally E WenzelDivision of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Mario CastroDepartments of Internal Medicine and Pediatrics, Washington University School of Medicine, St. Louis, Missouri, USA.
Sean B FainDepartments of Radiology and Medicine, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin, USA.
Nizar N JarjourDepartments of Radiology and Medicine, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin, USA.
Mark L SchieblerDepartments of Radiology and Medicine, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin, USA.
R Graham BarrMailman School of Public Health, Columbia University, New York, USA.
MeiLan K HanDepartment of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Eugene R BleeckerCenter for Genomics and Personalized Medicine, Wake Forest University, Winston-Salem, North Carolina, USA.
Christopher B CooperDepartment of Physiology, University of California, Los Angeles, California, USA.
David CouperDepartment of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, USA.
Nadia HanselSchool of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Richard E KannerSchool of Medicine, University of Utah, Salt Lake City, Utah, USA.
Ella A KazerooniDepartment of Radiology, University of Michigan, Ann Arbor, Michigan, USA.
Eric A C KleerupDepartment of Medicine, University of California, Los Angeles, Los Angeles, California, USA.
Fernando J MartinezDepartment of Medicine, Weill Cornell School of Medicine, Cornell University, New York, USA.
Wanda K O'NealMarsico Lung Institute, University of North Carolina, Chapel Hill, North Carolina, USA.
Prescott G WoodruffSchool of Medicine, University of California at San Francisco, San Francisco, California, USA.
Ching-Long LinDepartment of Mechanical and Industrial Engineering, University of Iowa, Iowa City, Iowa, USA.
University of Iowa · USUniversity of Wisconsin–Madison · USUniversity of California, Los Angeles · USUniversity of Michigan–Ann Arbor · USColumbia University · USCornell University · USJohns Hopkins Medicine · USKyungpook National University · KRLung Institute · USUniversity of California, San Francisco · USUniversity of North Carolina at Chapel Hill · USUniversity of Pittsburgh · USUniversity of Utah · USWake Forest University · USWashington University in St. Louis · US

Funding

WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
UNIVERSITY OF PITTSBURGH CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTE: BPCAUL1RR024153 · NCRR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2006 to 2011
$73.9M
Washington University Institute of Clinical and Translational SciencesUL1TR000448 · NCATS · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2012 to 2016
$41.4M
Institutional Clinical and Translational Science AwardUL1TR000427 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI DREZNER, MARC KENNETH · 2012 to 2016
$32.2M
Image and Model Based Analysis of Lung DiseasesR01HL064368 · NHLBI · UNIVERSITY OF IOWA · PI HOFFMAN, ERIC ALFRED · 1999 to 2009
$15.6M
Severe Asthma Research ProjectR01HL069174 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI WENZEL, SALLY E · 2001 to 2010
$9.2M
Severe Asthma From Respiratory InfectionsR01HL069116 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI BUSSE, WILLIAM W. · 2001 to 2010
$7.6M
Multi-center Structural & Functional Quantitative CT Pulmonary PhenotypingR01HL112986 · NHLBI · UNIVERSITY OF IOWA · PI HOFFMAN, ERIC ALFRED · 2012 to 2016
$4.6M
Stability of Severe Asthma Phenotypes: Impact of ExacerbationsU10HL109168 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI JARJOUR, NIZAR N · 2011 to 2016
$3.9M
Severe Asthma Research Program (SARP)-Washington UniversityU10HL109257 · NHLBI · WASHINGTON UNIVERSITY · PI CASTRO, MARIO · 2011 to 2016
$3.8M
An integrative statistics-guided image-based multi-scale lung modelU01HL114494 · NHLBI · UNIVERSITY OF IOWA · PI LIN, CHING-LONG · 2013 to 2017
$3.1M
SEVERE ASTHMA RESEARCH PROGRAM (SARPII) IMAGING CORER01HL091762 · NHLBI · WASHINGTON UNIVERSITY · PI CASTRO, MARIO · 2008 to 2011
$1.6M
NCATS NIH HHS UL1 TR000427NCATS NIH HHS UL1 TR000448NCATS NIH HHS UL1 TR002345NCRR NIH HHS S10 RR022421NCRR NIH HHS UL1 RR024153NHLBI NIH HHS HHSN268200900013CNHLBI NIH HHS HHSN268200900014CNHLBI NIH HHS HHSN268200900015CNHLBI NIH HHS HHSN268200900016CNHLBI NIH HHS HHSN268200900017CNHLBI NIH HHS HHSN268200900018CNHLBI NIH HHS HHSN268200900019CNHLBI NIH HHS HHSN268200900020CNHLBI NIH HHS R01 HL064368NHLBI NIH HHS R01 HL069116NHLBI NIH HHS R01 HL069174NHLBI NIH HHS R01 HL091762NHLBI NIH HHS R01 HL094315NHLBI NIH HHS R01 HL112986NHLBI NIH HHS U01 HL114494NHLBI NIH HHS U10 HL109168NHLBI NIH HHS U10 HL109257
6 · The paper itself

Abstract

Introduction: Quantitative CT (QCT) imaging-based metrics have quantified disease alterations in asthma and chronic obstructive pulmonary disease (COPD), respectively. We seek to characterise the similarity and disparity between these groups using QCT-derived airway and parenchymal metrics. Methods: Asthma and COPD subjects (former-smoker status) were selected with a criterion of post-bronchodilator FEV Results: Compared with healthy subjects, both asthma and COPD subjects demonstrated a decreased airway circularity especially in large and upper lobar airways, and a decreased normalised hydraulic diameter in segmental airways. Besides, COPD subjects had more severe emphysema and small-airway disease, as well as smaller regional tissue fraction and lung deformation, compared with asthmatic subjects. The difference of emphysema, small-airway disease and tissue fraction between asthma and COPD was more prominent in upper and middle lobes. Conclusions: Patients with asthma and COPD, with a persistent FEV

Indexed as

airway luminal narrowingemphysemafunctional small airway diseaseimage registrationquantitative computed tomography

Identifiers

PMID29435345
PMCPMC5687530
OpenAlexW2767210963

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.