ArticleBMJ open respiratory research2017
Predictive value of prebronchodilator and postbronchodilator spirometry for COPD features and outcomes.
Article in BMJ open respiratory research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Predictors of Acute Exacerbations in COPD: A Systematic Review.International journal of chronic obstructive pulmonary disease · 2026Pooled it
- GOLD Science Committee recommendations for the use of pre- and post-bronchodilator spirometry for the diagnosis of COPD.The European respiratory journal · 2025Guideline
- Association of non-obstructive dyspnoea with all-cause mortality and incident chronic obstructive pulmonary disease: a systematic literature review and meta-analysis.BMJ open respiratory research · 2024Pooled it
- Derivation and validation of a pre-bronchodilator FEV1/FVC threshold for point-of-care diagnosis triage of COPD in primary care: a multi-cohort population-based study.The Lancet regional health. Western Pacific · 2026Article
- Joint statement from GOLD/GLI regarding the use of spirometry to define airflow obstruction and diagnose COPD.The European respiratory journal · 2026Article
- Prevalence and risk factors of airflow obstruction in Southwest China: baseline findings from a multi-center population-based cohort study.BMC pulmonary medicine · 2026Article
- Impact of bronchodilator responsiveness on lung age in patients with respiratory diseases and/or symptoms: implications for clinical practice from a cross-sectional study.Journal of thoracic disease · 2026Article
- Gradual Increase in Lung Cancer Risk Due to Particulate Matter Exposure in Patients With Pulmonary Function Impairments: A Nationwide Korean Database Analysis.Journal of Korean medical science · 2025Article
- What's new in the 2025 GOLD report.Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia · 2025Article
- Early Diagnosis and Treatment of Chronic Obstructive Pulmonary Disease: The Costs and Benefits of Case Finding.American journal of respiratory and critical care medicine · 2024Article
- Obstructive and restrictive spirometry from school age to adulthood: three birth cohort studies.EClinicalMedicine · 2024Article
- Investigation of time profile of FEVScientific reports · 2023Article
- Should We Consider Screening Spirometry in Individuals Who Are "Asymptomatic"?Annals of the American Thoracic Society · 2022Article
- Pooled Cohort Probability Score for Subclinical Airflow Obstruction.Annals of the American Thoracic Society · 2022Article
- Significance of FEVChest · 2022Observational
- Spirometry for the diagnosis of airway obstruction in patients with risk factors for COPD: the GOLD and lower limit of normal criteria.Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia · 2022Observational
- Discharge Plan to Promote Patient Safety and Shared Decision Making by a Multidisciplinary Team of Healthcare Professionals in a Respiratory Unit.Nursing reports (Pavia, Italy) · 2021Article
- Ratio of FEVChest · 2021Observational
- Preserved Ratio Impaired Spirometry in a Spirometry Database.Respiratory care · 2021Article
- Article
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Authors and funding
4 authors.
Funding
Abstract
introductionWe compared the predictive value of prebronchodilator and postbronchodilator spirometry for chronic obstructive pulmonary disease (COPD) features and outcomes.
methodsWe analysed COPDGene data of 10 192 subjects with smoking history. We created regressions models with the following dependent variables: clinical, functional and radiographic features, and the following independent variables: prebronchodilator airflow obstruction (PREO) and postbronchodilator airflow obstruction (POSTO), prebronchodilator and postbronchodilator FEV
resultsThe COPD prevalence was higher using PREO. About 8.5% had PREO but no airflow obstruction in postbronchodilator spirometry (POSTN) (PREO-POSTN) and 3% of all subjects had no aiflow obstruction in prebronchodilator spirometry (PREN) but POSTO (PREN-POSTO). We found no difference in COPD features and outcomes between PREO-POSTN and PREN-POSTO subjects. Although, both prebronchodilator and postbronchodilator spirometries are both associated with chronic bronchitis, dyspnoea, exercise capacity and COPD radiographic findings, models that included postbronchodilator spirometric measures performed better than models with prebronchodilator measures to predict these COPD features. The predictive value of prebronchodilator and postbronchodilator spirometries for respiratory exacerbations, change in forced expiratory volume in 1 s, dyspnoea and exercise capacity during a 5-year period is relatively similar, but postbronchodilator spirometric measures are better predictors of mortality based on AIC.
conclusionsPostbronchodilator spirometry may be a more accurate predictor of COPD features and outcomes.
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