ArticleOncotarget2018
Co-expression analysis revealed PTCH1-3'UTR promoted cell migration and invasion by activating miR-101-3p/SLC39A6 axis in non-small cell lung cancer: implicating the novel function of PTCH1.
Article in Oncotarget, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 26 citations in OpenAlex.
- MicroRNA-regulated signaling and tumor microenvironment modulation in lung cancer: mechanistic insights and translational opportunities.Cancer cell international · 2026Review
- Advances in the basic function of the small GTPase SAR1B and its regulatory role in the biological behavior of tumor cells (Review).Molecular and clinical oncology · 2026Review
- Coding, or non-coding, that is the question.Cell research · 2024Review
- MiR-101-3p targets KPNA2 to inhibit the progression of lung squamous cell carcinoma cell lines.Histology and histopathology · 2023Article
- Prognostic significance of PD-L1 expression and CD8Journal of thoracic disease · 2022Article
- Role of SLC39A6 in the development and progression of liver cancer.Oncology letters · 2022Article
- RSPH14 regulates the proliferation, cell cycle progression, and apoptosis of non-small cell lung cancer cells.FEBS open bio · 2021Article
- Competing endogenous RNAs in lung cancer.Cancer biology & medicine · 2021Review
- Article
- Comprehensive Analysis of RNA Expression Profile Identifies Hub miRNA-circRNA Interaction Networks in the Hypoxic Ischemic Encephalopathy.Computational and mathematical methods in medicine · 2021Article
- The Identification of Candidate Biomarkers and Pathways in Atherosclerosis by Integrated Bioinformatics Analysis.Computational and mathematical methods in medicine · 2021Article
- STARD4 promotes breast cancer cell malignancy.Oncology reports · 2020Article
- Knockdown of SAR1B suppresses proliferation and induces apoptosis of RKO colorectal cancer cells.Oncology letters · 2020Article
- CFIm25-regulated lncRNA acv3UTR promotes gastric tumorigenesis via miR-590-5p/YAP1 axis.Oncogene · 2020Article
- The New Biomarker for Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (CESC) Based on Public Database Mining.BioMed research international · 2020Article
- lncRNA PTAR promotes NSCLC cell proliferation, migration and invasion by sponging microRNA‑101.Molecular medicine reports · 2019Article
- RBAK is upregulated in non-small cell lung cancer and promotes cell migration and invasion.Experimental and therapeutic medicine · 2019Article
- Prognostic implications of decreased microRNA-101-3p expression in patients with non-small cell lung cancer.Oncology letters · 2018Article
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metastasis is the most common cause of mortality for non-small cell lung cancer (NSCLC). PTCH1, a receptor of Hedgehog (Hh) pathway, is reported to suppress cell proliferation. Interestingly, our previous study showed PTCH1 silencing promoted cell proliferation but inhibited cell migration and invasion of NSCLC cells. However, the precise mechanisms of PTCH1 regulating NSCLC metastasis remain unclear. PTCH1 has multiple splicing variants, which all share the same 3'UTR sequence, meanwhile, emerging studies have shown competing endogenous RNAs (ceRNAs) play important roles in regulating cancer progression. Therefore, we hypothesized the functions of PTCH1-3'UTR in NSCLC in present study to reveal its role as a ceRNA. Here, we find overexpression of PTCH1-3'UTR promotes cell migration, invasion and adhesion, but does not affect cell proliferation in NSCLC cells. By combining weighted correlation network analysis (WGCNA) analysis and experimental validation, we reported PTCH1-3'UTR acted as a sponge to absorb miR-101-3p and promoted SLC39A6 expression. Moreover, we observed low expression of miR-101-3p and PTCH1 and high SLC39A6 levels were positively correlated with NSCLC progression. Therefore, our results help to understand the function of PTCH1 in NSCLC tumorigenesis and provide novel insights for the prevention of NSCLC metastasis.
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