Evidence map›Paper›PMID 29435129›Full record

ArticleOncotarget2018

Computational methods reveal novel functionalities of PIWI-interacting RNAs in human papillomavirus-induced head and neck squamous cell carcinoma.

Aswini R Krishnan, Yuanhao Qu, Pin Xue Li, Angela E Zou, Joseph A Califano, Jessica Wang-Rodriguez, Weg M Ongkeko

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
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  4. piRNA associates with immune diseases.Cell communication and signaling : CCS · 2024
    Review
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  6. Review
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  9. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Aswini R Krishnan *Department of Otolaryngology-Head and Neck Surgery, University of California San Diego, La Jolla, California, USA.
Yuanhao Qu *Department of Otolaryngology-Head and Neck Surgery, University of California San Diego, La Jolla, California, USA.
Pin Xue LiDepartment of Otolaryngology-Head and Neck Surgery, University of California San Diego, La Jolla, California, USA.
Angela E ZouDepartment of Otolaryngology-Head and Neck Surgery, University of California San Diego, La Jolla, California, USA.
Joseph A CalifanoDepartment of Otolaryngology-Head and Neck Surgery, University of California San Diego, La Jolla, California, USA.
Jessica Wang-RodriguezVeterans Administration San Diego Healthcare System and Department of Pathology, University of California San Diego, La Jolla, California, USA.
Weg M OngkekoDepartment of Otolaryngology-Head and Neck Surgery, University of California San Diego, La Jolla, California, USA.
University of California, San Diego · USVA San Diego Healthcare System · US

Funding

Non-coding RNAs in salivary gland tumorR21DE023242 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ONGKEKO, RUTHERFORD M · 2012 to 2013
$417k
NIDCR NIH HHS R21 DE023242
6 · The paper itself

Abstract

Human papillomavirus (HPV) infection is the fastest growing cause of head and neck squamous cell carcinoma (HNSCC) today, but its role in malignant transformation remains unclear. This study aimed to conduct a comprehensive investigation of PIWI-interacting RNA (piRNA) alterations and functionalities in HPV-induced HNSCC. Using 77 RNA-sequencing datasets from TCGA, we examined differential expression of piRNAs between HPV16(+) HNSCC and HPV(-) Normal samples, identifying a panel of 30 HPV-dysregulated piRNAs. We then computationally investigated the potential mechanistic significances of these transcripts in HPV-induced HNSCC, identifying our panel of piRNAs to associate with the protein PIWIL4 as well as the RTL family of retrotransposon-like genes, possibly through direct binding interactions. We also recognized several HPV-dysregulated transcripts for their correlations with well-documented mutations and copy number variations in HNSCC as well as HNSCC clinical variables, demonstrating the potential ability of our piRNAs to play important roles in large-scale modulation of HNSCC in addition to their direct, smaller-scale interactions in this malignancy. The differential expression of key piRNAs, including

Indexed as

HNSCCHPVncRNApiRNA

Identifiers

PMID29435129
PMCPMC5797000
OpenAlexW2778263369

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.