Evidence map›Paper›PMID 29434815›Full record

ArticleExperimental and therapeutic medicine2018

Dopamine receptor D4 promoter hypermethylation increases the risk of drug addiction.

Huihui Ji, Xuting Xu, Guili Liu, Huifen Liu, Qinwen Wang, Wenwen Shen, Longhui Li, Xiaohu Xie, Haochang Hu, Lei Xu and 2 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental and therapeutic medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. The Dopamine Receptor D4 Gene (Frontiers in behavioral neuroscience · 2018
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Huihui JiMedical Genetics Center, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, P.R. China.
Xuting XuMedical Genetics Center, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, P.R. China.
Guili LiuMedical Genetics Center, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, P.R. China.
Huifen LiuLaboratory of Behavioral Neuroscience, Ningbo Addiction Research and Treatment Center, Ningbo, Zhejiang 315010, P.R. China.
Qinwen WangMedical Genetics Center, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, P.R. China.
Wenwen ShenLaboratory of Behavioral Neuroscience, Ningbo Addiction Research and Treatment Center, Ningbo, Zhejiang 315010, P.R. China.
Longhui LiLaboratory of Behavioral Neuroscience, Ningbo Addiction Research and Treatment Center, Ningbo, Zhejiang 315010, P.R. China.
Xiaohu XieLaboratory of Behavioral Neuroscience, Ningbo Addiction Research and Treatment Center, Ningbo, Zhejiang 315010, P.R. China.
Haochang HuMedical Genetics Center, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, P.R. China.
Lei XuMedical Genetics Center, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, P.R. China.
Wenhua ZhouLaboratory of Behavioral Neuroscience, Ningbo Addiction Research and Treatment Center, Ningbo, Zhejiang 315010, P.R. China.
Shiwei DuanMedical Genetics Center, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, P.R. China.
Ningbo University · CNUniversity of Nottingham Ningbo China · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Heroin and methylamphetamine (METH) are two addictive drugs that cause serious problems for society. Dopamine receptor D4 (DRD4), a key receptor in the dopaminergic system, may facilitate the development of drug addiction. The aim of the present study was to investigate the association between the promoter methylation level of

Indexed as

DNA methylationDRD4heroinmethylamphetamine

Identifiers

PMID29434815
PMCPMC5776619
OpenAlexW2775208409

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.