Evidence map›Paper›PMID 29434762›Full record

ArticleExperimental and therapeutic medicine2018

Parathyroid hormone promotes osteoblastic differentiation of endothelial cells via the extracellular signal-regulated protein kinase 1/2 and nuclear factor-κB signaling pathways.

Zhi-Yuan Cheng, Ting Ye, Qiu-Yang Ling, Ting Wu, Gang-Yong Wu, Gang-Jun Zong

Open access · diamondAbstract read
In one paragraph

Article in Experimental and therapeutic medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Hyperparathyroidism and Peripheral Arterial Disease.Current vascular pharmacology · 2024
    Review
  8. Similarities and Differences of Vascular Calcification in Diabetes and Chronic Kidney Disease.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Exploring the Effect of Jiawei Buguzhi Pills on TGF-Evidence-based complementary and alternative medicine : eCAM · 2021
    Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Anabolic Therapies in Osteoporosis and Bone Regeneration.International journal of molecular sciences · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Zhi-Yuan ChengDepartment of Cardiology, Wuxi Clinical Hospital, Anhui Medical University, Wuxi, Jiangsu 214044, P.R. China.
Ting YeDepartment of Cardiology, Wuxi Clinical Hospital, Anhui Medical University, Wuxi, Jiangsu 214044, P.R. China.
Qiu-Yang LingDepartment of Cardiology, 101 Hospital of PLA, Wuxi, Jiangsu 214044, P.R. China.
Ting WuDepartment of Cardiology, 101 Hospital of PLA, Wuxi, Jiangsu 214044, P.R. China.
Gang-Yong WuDepartment of Cardiology, 101 Hospital of PLA, Wuxi, Jiangsu 214044, P.R. China.
Gang-Jun ZongDepartment of Cardiology, Wuxi Clinical Hospital, Anhui Medical University, Wuxi, Jiangsu 214044, P.R. China.
Anhui Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vascular calcification (VC) occurs in patients with chronic kidney disease (CKD) and contributes to cardiovascular dysfunction and mortality. Parathyroid hormone (PTH) is a crucial regulator of VC. High PTH serum levels constitute as a major risk factor for patients with CKD. However, the effect and mechanism of PTH on osteoblastic differentiation in endothelial cells have not been fully elucidated. In the present study, the role of PTH in VC was investigated using an

Indexed as

chronic kidney diseaseendothelial cellsextracellular signal-regulated protein kinase 1/2 signaling pathwaynuclear factor-κB signaling pathwayparathyroid hormonevascular calcification

Identifiers

PMID29434762
PMCPMC5774494
OpenAlexW2769034666

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.