Evidence map›Paper›PMID 29434648›Full record

ArticleNutrition & metabolism2018

Hsp90β knockdown in DIO mice reverses insulin resistance and improves glucose tolerance.

Enxuan Jing, Pragalath Sundararajan, Ishita Deb Majumdar, Suwagmani Hazarika, Samantha Fowler, Angela Szeto, Stephane Gesta, Armando J Mendez, Vivek K Vishnudas, Rangaprasad Sarangarajan and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrition & metabolism, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 34 citations in OpenAlex.

  1. Trial
  2. Relaxin-2: Shaping the Proteomic Landscape of Skeletal Muscle Physiology, Glucose Trafficking, and Mitochondrial Function in Rat.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  3. Article
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  5. Diabetes, Protein Misfolding, and Heat Stress: Molecular Insights and Translational Perspectives.TH open : companion journal to thrombosis and haemostasis · 2026
    Review
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  7. Article
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  9. Heliyon · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Enxuan JingBERG, LLC, 500 Old Connecticut Path, Bldg B (3rd Floor), Framingham, MA 01701 USA.
Pragalath SundararajanBERG, LLC, 500 Old Connecticut Path, Bldg B (3rd Floor), Framingham, MA 01701 USA.
Ishita Deb MajumdarBERG, LLC, 500 Old Connecticut Path, Bldg B (3rd Floor), Framingham, MA 01701 USA.
Suwagmani HazarikaBERG, LLC, 500 Old Connecticut Path, Bldg B (3rd Floor), Framingham, MA 01701 USA.
Samantha FowlerBERG, LLC, 500 Old Connecticut Path, Bldg B (3rd Floor), Framingham, MA 01701 USA.
Angela Szeto2Diabetes Research Institute, University of Miami Miller School of Medicine, University of Miami, Coral Gables, FL USA.
Stephane GestaBERG, LLC, 500 Old Connecticut Path, Bldg B (3rd Floor), Framingham, MA 01701 USA.
Armando J MendezBERG, LLC, 500 Old Connecticut Path, Bldg B (3rd Floor), Framingham, MA 01701 USA.
Vivek K VishnudasBERG, LLC, 500 Old Connecticut Path, Bldg B (3rd Floor), Framingham, MA 01701 USA.
Rangaprasad SarangarajanBERG, LLC, 500 Old Connecticut Path, Bldg B (3rd Floor), Framingham, MA 01701 USA.
Niven R NarainBERG, LLC, 500 Old Connecticut Path, Bldg B (3rd Floor), Framingham, MA 01701 USA.
University of Miami · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundInhibition of Hsp90 has been shown to improve glucose tolerance and insulin sensitivity in mouse models of diabetes. In the present report, the specific isoform Hsp90ab1, was identified as playing a major role in regulating insulin signaling and glucose metabolism.

methodsIn a diet-induced obese (DIO) mouse model of diabetes, expression of various Hsp90 isoforms in skeletal tissue was examined. Subsequent experiments characterized the role of Hsp90ab1 isoform in glucose metabolism and insulin signaling in primary human skeletal muscle myoblasts (HSMM) and a DIO mouse model.

resultsIn DIO mice

conclusionsThe data support a novel role for Hsp90ab1 in arbitrating skeletal muscle plasticity via modulation of substrate utilization including glucose and fatty acids in normal and disease conditions. Hsp90ab1 represents a novel target for potential treatment of metabolic disease including diabetes.

Indexed as

DiabetesGlucose metabolismHeat shock protein 90HyperglycemiaInsulin resistance

Identifiers

PMID29434648
PMCPMC5796506
OpenAlexW2786964269

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.