ArticleFrontiers in neurology2017
Cognitive Function and Serum Hormone Levels Are Associated with Gray Matter Volume Decline in Female Patients with Prolactinomas.
Article in Frontiers in neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- The impact of pituitary adenomas on cognitive performance: a systematic review.Frontiers in endocrinology · 2025Pooled it
- Gender differences in cognitive function in antipsychotic-treated chronic schizophrenia patients with hyperprolactinemia: a large-scale cross-sectional study.European archives of psychiatry and clinical neuroscience · 2026Article
- Unconsummated marriage: etiology and treatment of erectile dysfunction in newlywed men-a narrative review with a focus on China.Translational andrology and urology · 2026Review
- Subtle Cognitive Impairments and Psychological Complaints in Patients With Prolactinoma Despite Biochemical Control.The Journal of clinical endocrinology and metabolism · 2025Article
- Incarcerated adolescents scoring high on the Brown Attention-Deficit Disorder Scale are characterized by impairments within brain regions associated with executive control: A source-based morphometry study.Psychiatry research. Neuroimaging · 2025Article
- Effects of hyperprolactinemia and bromocriptine treatment on cerebral blood flow and functional brain States.Neuroradiology · 2025Article
- The Changing Treatment Paradigm for Prolactinoma-A Prospective Series of 100 Consecutive Neurosurgical Cases.The Journal of clinical endocrinology and metabolism · 2025Article
- Investigating the relationship between cognitive impairment and brain white matter tracts using diffusion tensor imaging in patients with prolactinoma.Journal of endocrinological investigation · 2025Article
- Neuropsychological complications of hypoprolactinemia.Reviews in endocrine & metabolic disorders · 2024Review
- The Association Between Prolactin Levels and Cognitive Function in Female Patients With Severe Mental Disorders.Psychiatry investigation · 2024Article
- Cognition and psychological wellbeing in hypopituitary patients.Reviews in endocrine & metabolic disorders · 2024Review
- The relationship between serum prolactin levels and cognitive function in drug-naïve schizophrenia patients: a cross-sectional study.Journal of neural transmission (Vienna, Austria : 1996) · 2024Article
- Multimodal Neuroimaging Computing: Basics and Applications in Neurosurgery.Advances in experimental medicine and biology · 2024Review
- Brain-derived neurotrophic factor, sex hormones and cognitive decline in male patients with schizophrenia receiving continuous antipsychotic therapy.World journal of psychiatry · 2023Article
- Neuropsychological Alterations of Prolactinomas' Cognitive Flexibility in Task Switching.Brain sciences · 2023Article
- Altered hemispheric asymmetry of attentional networks in patients with pituitary adenoma: an event-related potential study.Frontiers in neuroscience · 2023Article
- Hyperprolactinemia Associated with Attentional Processing and Interference Control Impairments in Patients with Prolactinomas.Brain sciences · 2022Article
- Prolactin Reduces Hippocampal Parvalbumin and GABAA Receptor Expression in Female Mice.Neuroendocrinology · 2022Article
- Role of ACE2-Ang (1-7)-Mas axis in post-COVID-19 complications and its dietary modulation.Molecular and cellular biochemistry · 2022Review
- Cognitive Deficit in Schizophrenia: From Etiology to Novel Treatments.International journal of molecular sciences · 2021Review
Corrections and comments
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Authors and funding
14 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectiveCognitive impairments have been reported in patients with hyperprolactinemia; however, there is a lack of knowledge of brain structure alterations relevant to hyperprolactinemia in prolactinomas. Thus, we aimed to identify changes in brain structure in prolactinomas and to determine whether these changes are related to cognitive performance and clinical characteristics.
methodsParticipants were 32 female patients with prolactinomas and 26 healthy controls (HC) matched for age, sex, education, and handedness. All participants underwent magnetic resonance imaging brain scans, neuropsychological assessments, and clinical evaluations. Voxel-based morphometry analysis was used to identify changes in gray matter volume (GMV). Partial correlation analysis and multiple linear regression were performed to determine the relationship between GMV, cognition, and clinical characteristics.
resultsCompared to HC, patients with prolactinomas demonstrated a decrease in GMV in the left hippocampus, left orbitofrontal cortex, right middle frontal cortex (MFC), and right inferior frontal cortex (IFC). In addition, patients performed worse than controls on tests for verbal memory and executive function, and this was significantly related to the GMV of the left hippocampus and right MFC, respectively. Moreover, in the patients, we found a negative relationship between serum prolactin levels and the GMV of the left hippocampus and right IFC, whereas a positive relationship was found between the GMV of the left hippocampus and serum levels of estradiol and luteinizing hormone.
conclusionIn patients with prolactinomas, specific brain structure abnormalities have been identified and are associated with cognitive impairments and dysfunctional hormones. This study enhances our understanding of brain structure changes that may occur with prolactinomas and provides novel and fundamental evidence for previous behavioral findings relevant to hyperprolactinemia.
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