ReviewNature neuroscience2018
Memory formation depends on both synapse-specific modifications of synaptic strength and cell-specific increases in excitability.
Review in Nature neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 175 papers, 1 of them a synthesis that pooled it.
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Who cites it
175 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Memory and Cognition-Related Neuroplasticity Enhancement by Transcranial Direct Current Stimulation in Rodents: A Systematic Review.Neural plasticity · 2020Pooled it
- Sleep deprivation impairs ventral hippocampus-medial prefrontal connectivity and task learning in rats.iScience · 2026Article
- METTL3/IGF2BP1 Axis Orchestrates m6A-Dependent NCAM1 Preservation to Combat Age-Related Cognitive Decline.Cells · 2026Article
- PTPRO Governs Synaptic Density, Long-Term Potentiation and Cognitive Function In Vivo.Neuroscience bulletin · 2026Article
- Visual learning at fast and slow timescales is driven by distinct plasticity rules in primate inferotemporal cortex.Nature communications · 2026Article
- Biophysical mechanisms underlying the generation and maintenance of rule-learning engram.Communications biology · 2026Article
- The hippocampal CA3 area implements sequence learning of discontinuous episodes.Communications biology · 2026Article
- Activity induced GEM-4/Copine expression inhibits gap junctions and promotes thermosensory plasticity.bioRxiv : the preprint server for biology · 2026Article
- Review
- Single-Field Evolution Rule Governs the Dynamics of Representational Drift in Mouse Hippocampal Dorsal CA1 Region.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Dynamic control of Raf-ERK signaling modulates neuronal activity across biological scales.bioRxiv : the preprint server for biology · 2026Article
- Enhancement of response learning in male rats with intrastriatal infusions of a BDNF -TrkB agonist, 7,8-dihydroxyflavone.Behavioural brain research · 2026Article
- A role for Fis1 in dendritic development.Scientific reports · 2025Article
- Boosting Brain Clean-Up: Can Targeting UPS Genes Offer Neuroprotection?Molecular neurobiology · 2025Review
- Temporal dynamics of Purkinje cell-intrinsic excitability governs cerebellar systems consolidation.iScience · 2025Article
- Long Term High-Salt Diet Induces Cognitive Impairments via Down-Regulating SHANK1.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Activity-dependent phosphorylation of CDYL by CDK5 regulates fear memory in mice.Translational psychiatry · 2025Article
- Ephrin-B2 deletion in GABAergic neurons induces cognitive deficits associated with single-nucleus transcriptomic differences in the prefrontal cortex.BMC biology · 2025Article
- Serum BDNF and progression to MCI in cognitively normal older adults: A prospective cohort study.The journal of prevention of Alzheimer's disease · 2025Article
- Ephaptic conduction molding memory engrams.BMC biology · 2025Article
115 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors.
Funding
Abstract
The modification of synaptic strength produced by long-term potentiation (LTP) is widely thought to underlie memory storage. Indeed, given that hippocampal pyramidal neurons have >10,000 independently modifiable synapses, the potential for information storage by synaptic modification is enormous. However, recent work suggests that CREB-mediated global changes in neuronal excitability also play a critical role in memory formation. Because these global changes have a modest capacity for information storage compared with that of synaptic plasticity, their importance for memory function has been unclear. Here we review the newly emerging evidence for CREB-dependent control of excitability and discuss two possible mechanisms. First, the CREB-dependent transient change in neuronal excitability performs a memory-allocation function ensuring that memory is stored in ways that facilitate effective linking of events with temporal proximity (hours). Second, these changes may promote cell-assembly formation during the memory-consolidation phase. It has been unclear whether such global excitability changes and local synaptic mechanisms are complementary. Here we argue that the two mechanisms can work together to promote useful memory function.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.