Evidence map›Paper›PMID 29434354›Full record

ArticleNature immunology2018

Single-cell gene expression reveals a landscape of regulatory T cell phenotypes shaped by the TCR.

David Zemmour, Rapolas Zilionis, Evgeny Kiner, Allon M Klein, Diane Mathis, Christophe Benoist

Erratum issuedOpen access · bronzeAbstract read
In one paragraph

Article in Nature immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 254 papers.

0numbers the graph read from it
0cells of the map it votes in
254citing papers in PubMed
20.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

254 citing papers in PubMed, 385 citations in OpenAlex.

  1. Gliadin-specific CD4Science advances · 2026
    Article
  2. A Gene-Program Architecture of Mouse T cells.bioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Article
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  6. Article
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  9. Article
  10. CNS1-dependent regulatory T cells shape recovery from acute lung injury.Journal of immunology (Baltimore, Md. : 1950) · 2026
    Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Review
  16. PasteurizedFrontiers in immunology · 2026
    Article
  17. CD25Frontiers in immunology · 2026
    Article
  18. Article
  19. Review
  20. Multimodal analysis definesbioRxiv : the preprint server for biology · 2025
    Article

194 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

David ZemmourDivision of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, and Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA.
Rapolas ZilionisDepartment of Systems Biology, Harvard Medical School, Boston, MA, USA.
Evgeny KinerDivision of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, and Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA.
Allon M KleinDepartment of Systems Biology, Harvard Medical School, Boston, MA, USA.
Diane MathisDivision of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, and Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA. dm@hms.harvard.edu.
Christophe BenoistDivision of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, and Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA. cbdm@hms.harvard.edu.ORCID 0000-0003-1172-6555
Brigham and Women's Hospital · USHarvard University · US

Funding

Naive T cell homeostasis: Treg selection and survivalR37AI051530 · NIAID · HARVARD MEDICAL SCHOOL · PI BENOIST, CHRISTOPHE O. · 2009 to 2018
$4.1M
Naive T cell survival: TCR and IL-7R signal interplayR01AI051530 · NIAID · JOSLIN DIABETES CENTER · PI BENOIST, CHRISTOPHE O. · 2002 to 2009
$2.4M
Specification of Treg cells: FOXP3 functional facetsR01AI116834 · NIAID · HARVARD MEDICAL SCHOOL · PI BENOIST, CHRISTOPHE O. · 2015 to 2019
$2.3M
T regulatory cell subsets at the microbial interface: determinism and functionR01AI125603 · NIAID · HARVARD MEDICAL SCHOOL · PI BENOIST, CHRISTOPHE O. · 2017 to 2021
$2.1M
NIAID NIH HHS R01 AI051530NIAID NIH HHS R01 AI116834NIAID NIH HHS R01 AI125603NIAID NIH HHS R37 AI051530
6 · The paper itself

Abstract

CD4

Indexed as

AnimalsHumansLymphocyte ActivationMicePhenotypeReceptors, Antigen, T-CellT-Lymphocytes, RegulatoryT-Lymphocyte SubsetsTranscriptomeReceptors, Antigen, T-Cell

Identifiers

PMID29434354
PMCPMC6069633
OpenAlexW2793411374

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.