ArticleModern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc2018
Glucocorticoid receptor expression in resident and hematopoietic cells in IgG4-related disease.
Article in Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 12 citations in OpenAlex.
- Does adjunctive endoscopic biliary drainage improve outcomes beyond glucocorticoids alone in IgG4-related pancreatobiliary disease?BMC gastroenterology · 2025Article
- IgG4-Related Cholangitis.Seminars in liver disease · 2025Review
- Fibroblast heterogeneity and tertiary lymphoid tissues in the kidney.Immunological reviews · 2021Review
- Tertiary lymphoid tissue in early-stage IgG4-related tubulointerstitial nephritis incidentally detected with a tumor lesion of the ureteropelvic junction: a case report.BMC nephrology · 2021Article
- Analysis of Corticosterone and Testosterone Synthesis in Rat Salivary Gland Homogenates.Frontiers in endocrinology · 2019Article
- Functional heterogeneity of resident fibroblasts in the kidney.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2019Review
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18 authors at 6 institutions in 1 country.
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Abstract
Immunoglobulin G4-related disease is a rare immune-mediated disease characterized by the infiltration of IgG4-positive plasma cells and unique storiform fibrosis of multiple organs. The majority of IgG4-related disease patients respond to glucocorticoids, yet the precise mechanism of their action remains unclear. Pathological sections of the submaxillary gland, kidney, and retroperitoneum from 20 patients in total diagnosed with IgG4-related disease were analyzed for glucocorticoid receptor expression and the cell types expressing glucocorticoid receptor. Strong and abundant expression of glucocorticoid receptor was observed in the submaxillary gland, kidney, and retroperitoneum of IgG4-related disease patients, while glucocorticoid receptor was rarely or only faintly observed in the submaxillary gland of patients with Sjögren's syndrome, radicular cysts and sialolithiasis or in the healthy kidney. Glucocorticoid receptor was mainly expressed in fibro/myofibroblasts, CD4-positive T cells and IgG4-positive plasma cells in the submandibular glands and kidneys of IgG4-related disease patients. The abundant expression of glucocorticoid receptor in various types of cells, including resident fibro/myofibroblasts in IgG4-related disease patients might provide clues to the mechanism of steroid responsiveness in IgG4-related disease patients.
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