Evidence map›Paper›PMID 29434326›Full record

ArticleNature microbiology2018

Culture-independent discovery of the malacidins as calcium-dependent antibiotics with activity against multidrug-resistant Gram-positive pathogens.

Bradley M Hover, Seong-Hwan Kim, Micah Katz, Zachary Charlop-Powers, Jeremy G Owen, Melinda A Ternei, Jeffrey Maniko, Andreia B Estrela, Henrik Molina, Steven Park and 2 more

Open access · hybridAbstract readLetter
In one paragraph

Article in Nature microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 187 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
187citing papers in PubMed, 1 pooled it
37.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

187 citing papers in PubMed, 1 synthesis or guideline pooled it, 420 citations in OpenAlex.

  1. Bactericidal activity of silver nanoparticles in drug-resistant bacteria.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2023
    Pooled it
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  19. Mechanism, Efficacy, and Safety of Natural Antibiotics.Antibiotics (Basel, Switzerland) · 2025
    Review
  20. Article

127 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Bradley M HoverLaboratory of Genetically Encoded Small Molecules, The Rockefeller University, New York, NY, USA.
Seong-Hwan KimLaboratory of Genetically Encoded Small Molecules, The Rockefeller University, New York, NY, USA.
Micah KatzLaboratory of Genetically Encoded Small Molecules, The Rockefeller University, New York, NY, USA.
Zachary Charlop-PowersLaboratory of Genetically Encoded Small Molecules, The Rockefeller University, New York, NY, USA.ORCID 0000-0001-8816-4680
Jeremy G OwenLaboratory of Genetically Encoded Small Molecules, The Rockefeller University, New York, NY, USA.
Melinda A TerneiLaboratory of Genetically Encoded Small Molecules, The Rockefeller University, New York, NY, USA.
Jeffrey ManikoLaboratory of Genetically Encoded Small Molecules, The Rockefeller University, New York, NY, USA.
Andreia B EstrelaLaboratory of Genetically Encoded Small Molecules, The Rockefeller University, New York, NY, USA.
Henrik MolinaProteomics Resource Center, The Rockefeller University, New York, NY, USA.
Steven ParkPublic Health Research Institute, Rutgers University-New Jersey Medical School, Newark, NJ, USA.
David S PerlinPublic Health Research Institute, Rutgers University-New Jersey Medical School, Newark, NJ, USA.
Sean F BradyLaboratory of Genetically Encoded Small Molecules, The Rockefeller University, New York, NY, USA. sbrady@rockefeller.edu.ORCID 0000-0001-5967-8586
Rockefeller University · USRutgers, The State University of New Jersey · US

Funding

Therapeutics for drug resistant-bacteria: Arylpropionyl-phloroglucinolsU19AI109713 · NIAID · RBHS-NEW JERSEY MEDICAL SCHOOL · PI LU, MIN · 2014 to 2018
$26.9M
A minimally invasive synthetic bio-driven approach for natural products discoveryU01GM110714 · NIGMS · ROCKEFELLER UNIVERSITY · PI BRADY, SEAN F · 2015 to 2019
$11.1M
Discovery of Antibiotics from Soil Microbiomes Using MetagenomicsR35GM122559 · NIGMS · ROCKEFELLER UNIVERSITY · PI SEAN F BRADY · 2017 to 2026
$4.7M
Selective Enrichment of Environmental DNA for Antibiotic Producing Gene ClustersF32AI110029 · NIAID · ROCKEFELLER UNIVERSITY · PI CHARLOP-POWERS, ZACHARY · 2014 to 2016
$175k
Antibiotics Around Us: Improving metagenome mining for the discovery of novel natural products from microbial communities.F32AI124479 · NIAID · ROCKEFELLER UNIVERSITY · PI HOVER, BRADLEY MORGAN · 2016 to 2016
$33k
NIAID NIH HHS F32 AI110029NIAID NIH HHS F32 AI124479NIAID NIH HHS U19 AI109713NIGMS NIH HHS R35 GM122559NIGMS NIH HHS U01 GM110714
6 · The paper itself

Abstract

Despite the wide availability of antibiotics, infectious diseases remain a leading cause of death worldwide

Indexed as

AnimalsAnti-Bacterial AgentsCalciumCell LineDaptomycinDrug Resistance, Multiple, BacterialHEK293 CellsHumansLipopeptidesMethicillin-Resistant Staphylococcus aureusMicrobial Sensitivity TestsPeptides, CyclicRatsSoil MicrobiologyStaphylococcal InfectionsAnti-Bacterial AgentsCalciumDaptomycinLipopeptidesmalacidinsPeptides, Cyclic

Identifiers

PMID29434326
PMCPMC5874163
OpenAlexW2789229938

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.