ArticleScientific reports2018
Quantification of glioblastoma mass effect by lateral ventricle displacement.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Association of TERT promoter mutation and MGMT methylation with MRI features and overall survival in glioblastoma, IDH-wildtype.Quantitative imaging in medicine and surgery · 2026Article
- Biomechanical mapping of tumor growth: A novel method to quantify glioma infiltration and mass effect.Medical physics · 2026Article
- FLAIR extending beyond a quadrant (FEQ) of the cerebrum as a qualitative imaging biomarker: a conceptual proposition and proof-of-principle.Clinical & experimental metastasis · 2025Article
- A review of applications of automated ventricular parcellation from magnetic resonance imaging of the brain.Frontiers in neurology · 2025Review
- The value of ventricular measurements in the prediction of shunt dependency after aneurysmal subarachnoid hemorrhage.Acta neurochirurgica · 2023Article
- Ensemble Inversion for Brain Tumor Growth Models With Mass Effect.IEEE transactions on medical imaging · 2023Article
- 3D finite-element brain modeling of lateral ventricular wall loading to rationalize periventricular white matter hyperintensity locations.Engineering with computers · 2022Article
- Coupling solid and fluid stresses with brain tumour growth and white matter tract deformations in a neuroimaging-informed model.Biomechanics and modeling in mechanobiology · 2022Article
- Spatiotemporal analysis of induced neural stem cell therapy to overcome advanced glioblastoma recurrence.Molecular therapy oncolytics · 2022Article
- Radiomic Deformation and Textural Heterogeneity (R-DepTH) Descriptor to Characterize Tumor Field Effect: Application to Survival Prediction in Glioblastoma.IEEE transactions on medical imaging · 2022Article
- Quantification of Tissue Compression Identifies High-Grade Glioma Patients with Reduced Survival.Cancers · 2022Article
- Modelling glioma progression, mass effect and intracranial pressure in patient anatomy.Journal of the Royal Society, Interface · 2022Article
- Pro-inflammatory cytokines in cystic glioblastoma: A quantitative study with a comparison with bacterial brain abscesses. With an MRI investigation of displacement and destruction of the brain tissue surrounding a glioblastoma.Frontiers in oncology · 2022Article
- Article
- Impact of initial midline shift in glioblastoma on survival.Neurosurgical review · 2021Article
- Glioblastomas located in proximity to the subventricular zone (SVZ) exhibited enrichment of gene expression profiles associated with the cancer stem cell state.Journal of neuro-oncology · 2020Article
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Authors and funding
7 authors.
Funding
Abstract
Mass effect has demonstrated prognostic significance for glioblastoma, but is poorly quantified. Here we define and characterize a novel neuroimaging parameter, lateral ventricle displacement (LVd), which quantifies mass effect in glioblastoma patients. LVd is defined as the magnitude of displacement from the center of mass of the lateral ventricle volume in glioblastoma patients relative to that a normal reference brain. Pre-operative MR images from 214 glioblastoma patients from The Cancer Imaging Archive (TCIA) were segmented using iterative probabilistic voxel labeling (IPVL). LVd, contrast enhancing volumes (CEV) and FLAIR hyper-intensity volumes (FHV) were determined. Associations with patient survival and tumor genomics were investigated using data from The Cancer Genome Atlas (TCGA). Glioblastoma patients had significantly higher LVd relative to patients without brain tumors. The variance of LVd was not explained by tumor volume, as defined by CEV or FLAIR. LVd was robustly associated with glioblastoma survival in Cox models which accounted for both age and Karnofsky's Performance Scale (KPS) (p = 0.006). Glioblastomas with higher LVd demonstrated increased expression of genes associated with tumor proliferation and decreased expression of genes associated with tumor invasion. Our results suggest LVd is a quantitative measure of glioblastoma mass effect and a prognostic imaging biomarker.
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