ArticleNature communications2018
The plant-specific histone residue Phe41 is important for genome-wide H3.1 distribution.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- TIME FOR COFFEE coordinates phase separation and chromatin regulation for salt tolerance.Science advances · 2026Article
- Genome-wide profiling and functional study of short N-terminal H2B variants in Arabidopsis.Journal of advanced research · 2025Article
- Epigenetics in the modern era of crop improvements.Science China. Life sciences · 2025Review
- Are complex traits underpinned by polygenic molecular traits? A reflection on the complexity of gene expression.Plant & cell physiology · 2025Review
- Single amino acid mutations in histone H3.3 illuminate the functional significance of H3K4 methylation in plants.Nature communications · 2025Article
- Functions and Mechanisms of Histone Modifications in Plants.Annual review of plant biology · 2025Review
- From chromatin to crop: epigenetic innovations in bioenergy systems.Frontiers in plant science · 2025Review
- The Histone Variant H3.3 Is Required for Plant Growth and Fertility inInternational journal of molecular sciences · 2024Article
- Mitotic inheritance of genetic and epigenetic information via the histone H3.1 variant.Current opinion in plant biology · 2023Review
- Advances in biological functions and mechanisms of histone variants in plants.Frontiers in genetics · 2023Review
- Histone H3.3 deposition in seed is essential for the post-embryonic developmental competence in Arabidopsis.Nature communications · 2022Article
- Genomic basis of the giga-chromosomes and giga-genome of tree peony Paeonia ostii.Nature communications · 2022Article
- Mutation of histone H3 serine 28 to alanine influences H3K27me3-mediated gene silencing in Arabidopsis thaliana.Plant physiology · 2022Article
- Histone chaperone ASF1 mediates H3.3-H4 deposition in Arabidopsis.Nature communications · 2022Article
- DNA polymerase epsilon binds histone H3.1-H4 and recruits MORC1 to mediate meiotic heterochromatin condensation.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- The Role of the TSK/TONSL-H3.1 Pathway in Maintaining Genome Stability in Multicellular Eukaryotes.International journal of molecular sciences · 2022Review
- Histone Variants in the Specialization of Plant Chromatin.Annual review of plant biology · 2022Review
- The histone H3.1 variant regulates TONSOKU-mediated DNA repair during replication.Science (New York, N.Y.) · 2022Article
- Histone variants and modifications during abiotic stress response.Frontiers in plant science · 2022Review
- The evolution and functional divergence of the histone H2B family in plants.PLoS genetics · 2020Article
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4 authors.
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Abstract
The dynamic incorporation of histone variants influences chromatin structure and many biological processes. In Arabidopsis, the canonical variant H3.1 differs from H3.3 in four residues, one of which (H3.1Phe41) is unique and conserved in plants. However, its evolutionary significance remains unclear. Here, we show that Phe41 first appeared in H3.1 in ferns and became stable during land plant evolution. Unlike H3.1, which is specifically enriched in silent regions, H3.1F41Y variants gain ectopic accumulation at actively transcribed regions. Reciprocal tail and core domain swap experiments between H3.1 and H3.3 show that the H3.1 core, while necessary, is insufficient to restrict H3.1 to silent regions. We conclude that the vascular-plant-specific Phe41 is critical for H3.1 genomic distribution and may act collaboratively with the H3.1 core to regulate deposition patterns. This study reveals that Phe41 may have evolved to provide additional regulation of histone deposition in plants.
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