ArticleScientific reports2018
Identification of novel PANDAR protein interaction partners involved in splicing regulation.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 211 citations in OpenAlex.
- CCAT2 role in gastrointestinal cancer progression and metastasis: a novel target for therapeutic strategies.Clinical and experimental medicine · 2025Review
- DeepLPI: a multimodal deep learning method for predicting the interactions between lncRNAs and protein isoforms.BMC bioinformatics · 2021Article
- The Biological Roles of lncRNAs and Future Prospects in Clinical Application.Diseases (Basel, Switzerland) · 2021Review
- Noncoding RNAs regulate alternative splicing in Cancer.Journal of experimental & clinical cancer research : CR · 2021Review
- The role of alternative splicing in human cancer progression.American journal of cancer research · 2021Review
- Long Non-Coding RNA-Ribonucleoprotein Networks in the Post-Transcriptional Control of Gene Expression.Non-coding RNA · 2020Review
- LncRNAs Regulatory Networks in Cellular Senescence.International journal of molecular sciences · 2019Review
- RNA Structure and Cellular Applications of Fluorescent Light-Up Aptamers.Angewandte Chemie (International ed. in English) · 2019Review
- Interactome determination of a Long Noncoding RNA implicated in Embryonic Stem Cell Self-Renewal.Scientific reports · 2018Article
- Epigenetic regulation of alternative splicing.American journal of cancer research · 2018Review
- Roles of PTBP1 in alternative splicing, glycolysis, and oncogensis.Journal of Zhejiang University. Science. BReview
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Interactions of long non-coding RNAs (lncRNA) with proteins play important roles in the regulation of many cellular processes. PANDAR (Promotor of CDKN1A Antisense DNA damage Activated RNA) is a lncRNA that is transcribed in a p53-dependent manner from the CDKN1A promoter and is involved in the regulation of proliferation and senescence. Overexpression of PANDAR has been observed in several tumor species and correlated with a poor prognosis for patient survival rate. Depending on the cellular state, PANDAR is known to interact with proteins such as the nuclear transcription factor Y subunit A (NF-YA) and the scaffold attachment factor A (SAF-A). However, a comprehensive analysis of the PANDAR interactome was missing so far. Therefore, we applied peptide nucleic acid (PNA)-based pull-downs combined with quantitative mass spectrometry to identify new protein binding partners. We confirmed potential candidates like U2AF65 and PTBP1, known to be involved in RNA processing. Furthermore, we observed that overexpression of PANDAR leads to a reduced level of the short pro-apoptotic BCL-X splice variant (BCL-XS) which is regulated by PTBP1. Simultaneous overexpression of PTBP1 was able to rescue this effect. Overall, our data suggest a role for PANDAR in the regulation of splicing events via its interaction partner PTBP1.
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