Evidence map›Paper›PMID 29434180›Full record

ArticleThe Kobe journal of medical sciences2018

Evaluation of a Small Animal Irradiation System for Animal Experiments Using EBT3 Model GAFCHROMIC™ Film.

Yasuyuki Shimizu, Hiroaki Akasaka, Daisuke Miyawaki, Naritoshi Mukumoto, Masao Nakayama, Tianyuan Wang, Saki Osuga, Sachiko Inubushi, Ryuichi Yada, Yasuo Ejima and 3 more

Abstract readComparative Study
PubMed Full text at PMC
In one paragraph

Article in The Kobe journal of medical sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yasuyuki ShimizuDivision of Radiation Oncology, Kobe University Graduate School of Medicine, 7-5-2 Kusunokicho, Chuo-ku, Kobe, Hyogo, 650-0017, Japan.
Hiroaki AkasakaDivision of Radiation Oncology, Kobe University Hospital, 7-5-2 Kusunokicho, Chuo-ku, Kobe, Hyogo, 650-0017, Japan.
Daisuke MiyawakiDivision of Radiation Oncology, Kobe University Graduate School of Medicine, 7-5-2 Kusunokicho, Chuo-ku, Kobe, Hyogo, 650-0017, Japan.
Naritoshi MukumotoDivision of Radiation Oncology, Kobe University Graduate School of Medicine, 7-5-2 Kusunokicho, Chuo-ku, Kobe, Hyogo, 650-0017, Japan.
Masao NakayamaDivision of Radiation Oncology, Kobe Minimally Invasive Cancer Center, 8-5-1, Minatojima-nakamachi, Chuo-ku, Kobe, Hyogo, 650-0046, Japan.
Tianyuan WangDivision of Radiation Oncology, Kobe University Graduate School of Medicine, 7-5-2 Kusunokicho, Chuo-ku, Kobe, Hyogo, 650-0017, Japan.
Saki OsugaDivision of Radiation Oncology, Kobe University Graduate School of Medicine, 7-5-2 Kusunokicho, Chuo-ku, Kobe, Hyogo, 650-0017, Japan.
Sachiko InubushiDivision of Radiation Oncology, Kobe University Graduate School of Medicine, 7-5-2 Kusunokicho, Chuo-ku, Kobe, Hyogo, 650-0017, Japan.
Ryuichi YadaDivision of Radiation Oncology, Kobe University Graduate School of Medicine, 7-5-2 Kusunokicho, Chuo-ku, Kobe, Hyogo, 650-0017, Japan.
Yasuo EjimaDivision of Radiation Oncology, Kobe University Hospital, 7-5-2 Kusunokicho, Chuo-ku, Kobe, Hyogo, 650-0017, Japan.
Kenji YoshidaDivision of Radiation Oncology, Kobe University Graduate School of Medicine, 7-5-2 Kusunokicho, Chuo-ku, Kobe, Hyogo, 650-0017, Japan.
Takeaki IshiharaDivision of Radiation Oncology, Kobe University Graduate School of Medicine, 7-5-2 Kusunokicho, Chuo-ku, Kobe, Hyogo, 650-0017, Japan.
Ryohei SasakiDivision of Radiation Oncology, Kobe University Graduate School of Medicine, 7-5-2 Kusunokicho, Chuo-ku, Kobe, Hyogo, 650-0017, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In cancer research, small animal models, for example, mice, rats, or rabbits, facilitate the in-depth study of biological processes and the effects of radiation treatment that can lead to breakthrough discoveries. However, the physical quality of small animal irradiation systems has not been previously evaluated. In this study, we evaluate the quality of a small animal irradiation system using GAFCHROMIC™ film and a Tough Water Phantom. The profiles and percentage depth dose curves for several irradiation conditions were measured to evaluate the quality of the irradiation system. The symmetry ratios when the table was rotated were 1.1 (no filter), 1.0 (0.5 mm Al filter), 1.0 (1.0 mm Al filter), 1.1 (2 mm Al filter), and 1.0 (filter consisting of 0.5 mm Al combined with 0.1 mm Cu). The results of measuring the percentage depth dose curve showed that the relative doses were 17.5% (10 mm depth), 12.4% (20 mm depth), 9.5% (30 mm depth), and 7.4% (40 mm filter) with no filters inserted, 78.0% (10 mm depth), 61.1% (20 mm depth), 46.9% (30 mm depth), and 35.3% (40 mm depth) when a 1.0 mm Al filter was inserted, and 94.4% (10 mm depth), 81.7% (20 mm depth), 68.1% (30 mm depth), and 54.7% (40 mm depth) when a filter consisting of 1.0 mm Al combined with 0.2 mm Cu was inserted. These physical assessments seem to be necessary especially in vivo experiments because those increase reliability of data obtained from small animal irradiation systems.

Indexed as

Radiation DosageAnimal ExperimentationAnimalsDose-Response Relationship, RadiationEquipment DesignFilm DosimetryIn Vivo DosimetryMiceModels, AnimalQuality ControlRabbitsRadiation MonitoringRatsSensitivity and SpecificitySkinAnimal experimentIrradiationQuality assuranceRadiation

Identifiers

PMID29434180
PMCPMC5826025

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.