Evidence map›Paper›PMID 29434078›Full record

ArticleThe Journal of reproduction and development2018

Fas-associated protein factor 1 is involved in meiotic resumption in mouse oocytes.

Hui Peng, Jianchao Huo, Yuyun Gao, Jing Chen, Xiang Yu, Tianfang Xiao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of reproduction and development, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Hui PengCollege of Animal Science, Fujian Agriculture and Forestry University, Fuzhou 350002, P. R. China.
Jianchao HuoCollege of Animal Science, Fujian Agriculture and Forestry University, Fuzhou 350002, P. R. China.
Yuyun GaoCollege of Animal Science, Fujian Agriculture and Forestry University, Fuzhou 350002, P. R. China.
Jing ChenCollege of Animal Science, Fujian Agriculture and Forestry University, Fuzhou 350002, P. R. China.
Xiang YuCollege of Animal Science, Fujian Agriculture and Forestry University, Fuzhou 350002, P. R. China.
Tianfang XiaoCollege of Animal Science, Fujian Agriculture and Forestry University, Fuzhou 350002, P. R. China.
Fujian Agriculture and Forestry University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fas-associated protein factor 1 (FAF1) is a Fas-associated protein that functions in multiple cellular processes. Previous research showed that mutations in Faf1 led to the lethality of cleavage stage embryos in a mouse model. The aim of the present study was to analyze the expression pattern, localization, and function of FAF1 in meiotic resumption of mouse oocytes. FAF1 was exclusively expressed in oocytes at various follicular stages within the ovary and was predominantly localized in the cytoplasm of growing oocytes. Furthermore, Faf1 mRNA and protein were persistently present during oocyte maturation and Faf1 mRNA levels were similar in the germinal vesicle (GV), GV breakdown (GVBD), and metaphase II (MII) stages of oocytes. Moreover, knockdown of Faf1 in GV-stage oocytes led to a significantly decreased rate of GVBD. To our knowledge, these results provide the first evidence regarding a novel function of FAF1 in meiotic resumption in mouse oocytes.

Indexed as

Gene Expression Regulation, DevelopmentalMitosisOogenesisActive Transport, Cell NucleusAdaptor Proteins, Signal TransducingAnimalsApoptosis Regulatory ProteinsCarrier ProteinsCell NucleusCell Nucleus ShapeCytoplasmFemaleImmunohistochemistryIntracellular Signaling Peptides and ProteinsIn Vitro Oocyte Maturation TechniquesMetaphaseAdaptor Proteins, Signal TransducingApoptosis Regulatory ProteinsCarrier ProteinsFaf1 protein, mouseIntracellular Signaling Peptides and ProteinsRNA, MessengerFAF1 proteinMeiotic resumptionMouseOocyte

Identifiers

PMID29434078
PMCPMC5902905
OpenAlexW2883644234

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.