Evidence map›Paper›PMID 29434035›Full record

ArticleRNA (New York, N.Y.)2018

Molecular dynamics correctly models the unusual major conformation of the GAGU RNA internal loop and with NMR reveals an unusual minor conformation.

Aleksandar Spasic, Scott D Kennedy, Laura Needham, Muthiah Manoharan, Ryszard Kierzek, Douglas H Turner, David H Mathews

Abstract read
In one paragraph

Article in RNA (New York, N.Y.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Aleksandar Spasic *Department of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, New York 14642, USA.
Scott D Kennedy *Department of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, New York 14642, USA.
Laura NeedhamDepartment of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, New York 14642, USA.
Muthiah ManoharanDepartment of Discovery, Alnylam Pharmaceuticals, Cambridge, Massachusetts 02142, USA.
Ryszard KierzekInstitute of Bioorganic Chemistry, Polish Academy of Sciences, 61-704 Poznan Noskowskiego, Poland.
Douglas H TurnerCenter for RNA Biology, University of Rochester Medical Center, Rochester, New York 14642, USA.
David H MathewsDepartment of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, New York 14642, USA.

Funding

KINETIC AND SPECTROSCOPIC STUDIES OF NUCLEIC ACIDSR01GM022939 · NIGMS · UNIVERSITY OF ROCHESTER · PI TURNER, DOUGLAS H. · 1985 to 2016
$7.6M
Supporting RNAstructure: Software for RNA AnalysisR01GM076485 · NIGMS · UNIVERSITY OF ROCHESTER · PI MATHEWS, DAVID H. · 2006 to 2021
$4.7M
NIGMS NIH HHS R01 GM022939NIGMS NIH HHS R01 GM076485
6 · The paper itself

Abstract

The RNA "GAGU" duplex, (5'GAC

Indexed as

Molecular Dynamics SimulationBase PairingGuanosineHydrogen BondingInosineNuclear Magnetic Resonance, BiomolecularNucleic Acid ConformationRNA, Double-StrandedGuanosineInosineRNA, Double-StrandedAmberGAGUmolecular dynamicsRNA internal loop

Identifiers

PMID29434035
PMCPMC5900564

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.