Evidence map›Paper›PMID 29433961›Full record

ReviewTrends in immunology2018

Immunology of the Uterine and Vaginal Mucosae.

Jordan Z Zhou, Sing Sing Way, Kang Chen

Erratum issuedAbstract readReview
PubMed Publisher
In one paragraph

Review in Trends in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 42 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Post-coital traumatic haemorrhage as cause of death.Forensic science, medicine, and pathology · 2026
    Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Review
  13. Understanding the Associations of Urogenital Microbiomes With Fertility and In Vitro Fertilization.American journal of reproductive immunology (New York, N.Y. : 1989) · 2025
    Review
  14. IgA and the gut-vagina axis.Frontiers in immunology · 2025
    Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Jordan Z ZhouDepartments of Obstetrics and Gynecology, Wayne State University, Detroit, MI 48201, USA; Center for Molecular Medicine and Genetics, Wayne State University, Detroit, MI 48201, USA; Perinatology Research Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Detroit, MI 48201, USA.
Sing Sing WayDivision of Infectious Disease, Cincinnati Children's Hospital, Cincinnati, OH 45229, USA; Perinatal Institute, Cincinnati Children's Hospital, Cincinnati, OH 45229, USA.
Kang ChenDepartments of Obstetrics and Gynecology, Wayne State University, Detroit, MI 48201, USA; Perinatology Research Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Detroit, MI 48201, USA; Jiangsu Hospital of Traditional Chinese Medicine, Nanjing, Jiangsu 210029, China; Mucosal Immunology Studies Team, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: kang@wayne.edu.

Funding

Immunological identity redefined by genetically foreign microchimeric cellsDP1AI131080 · NIAID · CINCINNATI CHILDRENS HOSP MED CTR · PI WAY, SING SING · 2016 to 2020
$5.5M
The Immune Pathogenesis of Prenatal Listeria monocytogenes InfectionR01AI100934 · NIAID · UNIVERSITY OF MINNESOTA · PI WAY, SING SING · 2012 to 2016
$2.3M
Maternal Regulatory T cell antigen-specificityR01AI120202 · NIAID · CINCINNATI CHILDRENS HOSP MED CTR · PI WAY, SING SING · 2016 to 2020
$1.9M
Mechanism of Humoral Immune Defects in Autoimmune Polyglandular Syndrome Type 1R21AI122256 · NIAID · WAYNE STATE UNIVERSITY · PI CHEN, KANG · 2016 to 2017
$419k
Howard Hughes Medical InstituteNIAID NIH HHS DP1 AI131080NIAID NIH HHS R01 AI100934NIAID NIH HHS R01 AI120202
6 · The paper itself

Abstract

Along with the maintenance of symbiotic mutualism with commensal microbes and protection against invasive infections common to all mucosal barrier tissues, female reproductive tissues have additional, unique tasks that include dynamic cyclic cellular turnover in menstruation and immunological tolerance to genetically foreign fetal antigens in pregnancy. Here we review current knowledge on distinct features of the immune cells in female reproductive tissue with regard to antimicrobial host defense and adaptations to accommodate the fetus during pregnancy. Outstanding areas for future research to obtain new functional insights on this enigmatic mucosal barrier are also highlighted.

Indexed as

AnimalsAnti-Infective AgentsFemaleFetusGenitalia, FemaleHumansImmune ToleranceMenstruationMucous MembranePregnancyUterusVaginaAnti-Infective Agents

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.