ArticleEpilepsy & behavior : E&B2018
Adherence barriers in pediatric epilepsy: From toddlers to young adults.
Article in Epilepsy & behavior : E&B, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- Barriers and enablers to antiseizure medication adherence in children with epilepsy: a systematic review using the theoretical domains framework (TDF).BMJ paediatrics open · 2026Pooled it
- Poor-tasting pediatric medicines: Part 1. A scoping review of their impact on patient acceptability, medication adherence, and treatment outcomes.Frontiers in drug delivery · 2025Pooled it
- A randomized clinical trial to support adherence regimens in children with epilepsy: Examining potential mechanisms of change.Epilepsy & behavior : E&B · 2023Trial
- Pilot randomized controlled clinical trial of an adherence social norms intervention for adolescents with epilepsy.Epilepsy & behavior : E&B · 2023Trial
- Key predictors of the need for a family-focused pediatric epilepsy adherence intervention.Epilepsia · 2022Trial
- Feasibility and acceptability of an innovative adherence intervention for young adults with childhood-onset systemic Lupus Erythematosus.Pediatric rheumatology online journal · 2020Trial
- Lipid Nanoparticles with Stiripentol and Cannabidiol Oil: From Rational Optimization to Preclinical Characterization.Pharmaceutics · 2026Article
- Best Practices in Clinical Epilepsy Symposium | Mortality in Epilepsy: Challenges and Interventions.Epilepsy currents · 2026Article
- Barriers to Medication Adherence in People Living With Epilepsy.Neurology. Clinical practice · 2025Article
- A qualitative analysis of clinician perspectives on community health worker integration at epilepsy centers.Frontiers in neurology · 2025Article
- Disparities in adolescent controller medication adherence, treatment barriers, and asthma control.Pediatric pulmonology · 2024Article
- Adherence in young people living with juvenile arthritis: A systematic review.Clinical practice in pediatric psychology · 2024Article
- The Effectiveness of Medical Adherence Mobile Health Solutions for Individuals With Epilepsy: Protocol for a Systematic Review.JMIR research protocols · 2024Article
- Feasibility pilot trial of a tailored medication adherence-promotion intervention for adolescents and young adults with cancer: Study design and protocol.Contemporary clinical trials · 2024Article
- Interventions to Improve Medication Adherence in Children With Epilepsy: A Systematic Review.Cureus · 2024Review
- Validation of an Italian Questionnaire of Adherence to the Ketogenic Dietary Therapies: iKetoCheck.Foods (Basel, Switzerland) · 2023Article
- Predictors of objective treatment adherence in adolescents with epilepsy: The important role of motivation.Epilepsy & behavior : E&B · 2023Article
- Demystifying a family-based epilepsy adherence problem-solving intervention: Exploring adherence barriers and solutions.Clinical practice in pediatric psychology · 2023Article
- A Cost-effectiveness Analysis of Adherence Promotion Strategies to Improve Rejection Rates in Adolescent Kidney Transplant Recipients.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2022Article
- Racial Disparities in Medication Adherence Barriers: Pediatric Epilepsy as an Exemplar.Journal of pediatric psychology · 2022Observational
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
objectiveThe objectives of this study were to examine the continuity of adherence barriers across stages of development in pediatric epilepsy and to assess the differential influence of barriers on several important clinical outcomes from early childhood to young adulthood, including adherence, seizures, and health-related quality of life (HRQOL).
methodA developmentally representative sample of youth 2-25years with epilepsy was obtained by combining data from five different studies. A total of 269 caregivers and 77 adolescents and young adults were included in this investigation. Participants completed measures of adherence barriers and HRQOL. An electronic monitoring system was used to assess adherence to the primary antiepileptic drug over 30days. The prevalence of individual barriers across development and their relative importance as predictors of clinical outcomes were examined.
resultsAdherence barriers are characterized by both continuity and discontinuity from early childhood to early adulthood. Barriers such as disliking the taste of medication, parent forgetfulness, and refusal to take medications were significantly more salient during certain developmental periods. No significant differences across age groups were found for other barriers, including difficulty getting to the pharmacy and embarrassment. Certain adherence barriers, such as running out of medications, were more important to particular clinical outcomes despite being low prevalence. Adherence barriers differentially predicted adherence, seizure control, and HRQOL based on developmental stage.
conclusionRoutine assessment of adherence barriers is imperative from toddlerhood to young adulthood given that the prevalence of barriers and their relative influence on important health outcomes vary by developmental stage. Adherence intervention efforts should be targeted, developmentally tailored, and focused on those barriers that are most predictive of poor outcomes for a given developmental period.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.