ReviewSeminars in fetal & neonatal medicine2018
Acute symptomatic seizures in term neonates: Etiologies and treatments.
Review in Seminars in fetal & neonatal medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 62 citations in OpenAlex.
- Electro-clinical efficacy and safety of midazolam in neonatal seizures: a systematic review with individual level exploratory analysis of gestational age-related treatment response.European journal of pediatrics · 2026Pooled it
- Treating the symptom or treating the disease in neonatal seizures: a systematic review of the literature.Italian journal of pediatrics · 2021Pooled it
- Neonatal arterial ischemic stroke: an imaging overview.Pediatric radiology · 2026Review
- Coexistence of 21-hydroxylase deficiency and Gitelman syndrome in a neonate presenting with severe hyponatremic seizures: a case report.Frontiers in endocrinology · 2026Article
- Grandmaternal Obesity and Risks of Birth Asphyxia-Related Complications in Grand-Offspring: A Countrywide Three-Generation Study.Obesity (Silver Spring, Md.) · 2025Article
- Topiramate for the treatment of neonatal seizures and beyond.Epilepsia · 2025Review
- Scaling convolutional neural networks achieves expert level seizure detection in neonatal EEG.NPJ digital medicine · 2025Article
- Efficacy of Levetiracetam vs Phenobarbital as First Line Therapy for the Treatment of Neonatal Seizures.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2024Article
- Whole-exome sequencing as the first-tier test for patients in neonatal intensive care unit: a Chinese single-center study.BMC pediatrics · 2024Observational
- Acute symptomatic seizures in newborns: a narrative review.Acta epileptologica · 2024Review
- Case Report: resolution of refractory seizures after neurosurgical intervention in newborns with cerebral extra-axial hemorrhages.Frontiers in pediatrics · 2024Article
- The Use of Midazolam as an Antiseizure Medication in Neonatal Seizures: Single Center Experience and Literature Review.CNS & neurological disorders drug targets · 2024Observational
- Questions and Controversies in Neonatal Seizures.Children (Basel, Switzerland) · 2023Review
- Neonatal brain MRI and short-term outcomes after acute provoked seizures.Journal of perinatology : official journal of the California Perinatal Association · 2023Article
- Behavioral and Cognitive Outcomes of Rhesus Macaques Following Neonatal Exposure to Antiseizure Medications.Annals of neurology · 2023Article
- Neuroprotective therapies in the NICU in term infants: present and future.Pediatric research · 2023Review
- Early Discontinuation of Phenobarbital After Acute Symptomatic Neonatal Seizures in the Term Newborn.Neurology. Clinical practice · 2023Article
- Detection and Severity Identification of Neonatal Seizure Using Deep Convolutional Neural Networks from Multichannel EEG Signal.Pediatric health, medicine and therapeutics · 2023Article
- Article
- Mild hypothermia fails to protect infant macaques from brain injury caused by prolonged exposure to Antiseizure drugs.Neurobiology of disease · 2022Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Acute symptomatic seizures caused by either diffuse or focal perinatal hypoxic-ischemic insults and intracranial hemorrhage in term newborns make up the large majority of all neonatal seizures. Acute seizures are one of the most common neurological disorders in term newborns who require admission to the neonatal intensive care unit. Despite elucidation of seizure pathogenesis in this population using animal models, treatment is limited by a lack of good evidence-based guidelines because of a paucity of rigorously conducted clinical trials or prospective studies in human newborns. A result of this knowledge gap is that management, particularly drug choice, is guided by clinical experience rather than by data informing drug efficacy and safety. This review summarizes the common etiologies and pathogenesis of acute symptomatic seizures, and the current data informing their treatment, including potential novel drugs, together with a suggested treatment algorithm.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.