Evidence map›Paper›PMID 29433560›Full record

ArticleBMC endocrine disorders2018

An international survey on hypoglycemia among insulin-treated type I and type II diabetes patients: Turkey cohort of the non-interventional IO HAT study.

Rıfat Emral, Tamer Tetiker, Ibrahim Sahin, Ramazan Sari, Ahmet Kaya, İlhan Yetkin, Sefika Uslu Cil, Neslihan Başcıl Tütüncü, IO HAT investigator group

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC endocrine disorders, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02306681 (An International Survey on Hypoglycaemia Among Insulin-treated Patients With Diabetes), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02306681 completednot on this map

An International Survey on Hypoglycaemia Among Insulin-treated Patients With Diabetes

TypeobservationalSponsorNovo Nordisk A/SRan2014 to 2015Enrolled7,315ConditionsDiabetes, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2ArmsNo treatment given
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 1 country.

Rıfat EmralDepartment of Endocrinology and Metabolic Diseases, Ankara University, Faculty of Medicine, İbn-i Sina Hospital, Academic Region M1/09, Samanpazarı, 06100, Ankara, Turkey. rifatemral@gmail.com.
Tamer TetikerFaculty of Medicine, Department of Endocrinology and Metabolic Diseases, Çukurova University, Adana, Turkey.
Ibrahim SahinEndocrinology and Metabolism Department, Inonu University School of Medicine, Malatya, Turkey.
Ramazan SariDivision of Endocrinology and Metabolism, School of Medicine, Akdeniz University, Antalya, Turkey.
Ahmet KayaDivision of Endocrinology and Metabolism, Meram School of Medicine, Necmettin Erbakan University, Konya, Turkey.
İlhan YetkinDivision of Endocrinology and Metabolism, School of Medicine, Gazi University, Ankara, Turkey.
Sefika Uslu CilMedical Department, Novo Nordisk, Istanbul, Turkey.
Neslihan Başcıl TütüncüDivision of Endocrinology and Metabolism, School of Medicine, Baskent University, Ankara, Turkey.
IO HAT investigator group
Akdeniz University · TRAnkara University · TRBaşkent University · TRGazi University · TRInonu University · TRNecmettin Erbakan University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLimited real-world data are currently available on hypoglycemia in diabetes patients. The International Operations Hypoglycemia Assessment Tool (IO HAT) study was designed to estimate hypoglycemia in insulin-treated type I (T1DM) and type II (T2DM) diabetes mellitus patients from 9 countries. The data from Turkey cohort are presented here.

methodsA non-interventional study to determine the hypoglycemia incidence, retrospectively and prospectively, in Turkish T1DM and T2DM patients using a 2-part self-assessment questionnaire.

resultsOverall, 2348 patients were enrolled in the Turkey cohort (T1DM = 306 patients, T2DM = 2042 patients). In T1DM patients, 96.8% patients reported hypoglycemic events (Incidence rate [IR]: 68.6 events per patient-year [ppy]), prospectively, while 74.0% patients reported hypoglycemic events (IR: 51.7 events ppy), retrospectively. In T2DM patients, 95.9% patients (IR: 28.3 events ppy) reported hypoglycemic events, prospectively, while 53.6% patients (IR: 23.0 events ppy) reported hypoglycemic events, retrospectively. Nearly all patients reported hypoglycemia during the prospective period.

conclusionsThis is a first patient-reported dataset on hypoglycemia in Turkish, insulin-treated diabetes patients. A high incidence of patient-reported hypoglycemia confirms that hypoglycemia remains under-estimated. Hypoglycemia increased healthcare utilization impacting patients' quality of life. Hypoglycemia remains a common side effect with insulin-treatment and strategies to optimize therapy and reduce hypoglycemia occurrence in diabetes patients are required.

trial registrationClinicaltrials.gov, NCT02306681 (Date of registration: 12 Nov 2014; retrospectively registered).

Indexed as

Quality of LifeAdultDiabetes Mellitus, Type 1Diabetes Mellitus, Type 2FemaleFollow-Up StudiesHumansHypoglycemiaHypoglycemic AgentsIncidenceInsulinInternational AgenciesMaleMiddle AgedPrognosisProspective StudiesHypoglycemic AgentsInsulinDiabetesHypoglycemiaInsulinIO HATNon-interventionalTurkey

Identifiers

PMID29433560
PMCPMC5809967
OpenAlexW2802616828

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.