Evidence map›Paper›PMID 29433501›Full record

ArticleBMC medicine2018

International core outcome set for clinical trials of medication review in multi-morbid older patients with polypharmacy.

Jean-Baptiste Beuscart, Wilma Knol, Shane Cullinan, Claudio Schneider, Olivia Dalleur, Benoit Boland, Stefanie Thevelin, Paul A F Jansen, Denis O'Mahony, Nicolas Rodondi and 1 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06688591 (Effectiveness of an Evidence-based Multi-component Intervention Programme to Reduce Medication-related Problems Among Polymedicated Home-dwelling Older Adults), which is not on this map. Cited by 71 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed, 7 pooled it
39.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06688591 nawithdrawnnot on this mapstarted 2021, after this paper: background citation

Effectiveness of an Evidence-based Multi-component Intervention Programme to Reduce Medication-related Problems Among Polymedicated Home-dwelling Older Adults: Protocol for a Multi-site Pilot Study of the OptiMed Clinical Trial

TypeinterventionalSponsorHES-SO Valais-WallisRan2021 to 2023Enrolled0ConditionsPolypharmacy, Multiple Chronic ConditionsArmsIntervention programme to optimise medication management and prevent MRPs
3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 7 syntheses or guidelines pooled it, 130 citations in OpenAlex.

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  8. Health-related quality of life among older adults following acute hospitalization: longitudinal analysis of a randomized controlled trial.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2024
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11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 8 institutions in 5 countries.

Jean-Baptiste BeuscartLouvain Drug Research Institute (LDRI), Clinical pharmacy research group, Université catholique de Louvain, Brussels, Belgium. jean-baptiste.beuscart@univ-lille2.fr.ORCID 0000-0002-0734-8371
Wilma KnolDepartment of Geriatric Medicine and Expertise Centre Pharmacotherapy in Old Persons, University Medical Centre Utrecht, Utrecht, The Netherlands.
Shane CullinanPharmaceutical Care Research Group, School of Pharmacy, Cavanagh Pharmacy Building, University College Cork, College Road, Cork, Ireland.
Claudio SchneiderDepartment of General Internal Medicine, Bern University Hospital, Bern, Switzerland.
Olivia DalleurLouvain Drug Research Institute (LDRI), Clinical pharmacy research group, Université catholique de Louvain, Brussels, Belgium.
Benoit BolandGeriatric Medicine, Cliniques universitaires Saint-Luc, Institut de Recherche Santé et Société, Université catholique de Louvain, Brussels, Belgium.
Stefanie ThevelinLouvain Drug Research Institute (LDRI), Clinical pharmacy research group, Université catholique de Louvain, Brussels, Belgium.
Paul A F JansenDepartment of Geriatric Medicine and Expertise Centre Pharmacotherapy in Old Persons, University Medical Centre Utrecht, Utrecht, The Netherlands.
Denis O'MahonyDepartment of Geriatric Medicine, Cork University Hospital and Department of Medicine, University College Cork, Cork, Ireland.
Nicolas RodondiDepartment of General Internal Medicine, Bern University Hospital, Bern, Switzerland.
Anne SpinewineLouvain Drug Research Institute (LDRI), Clinical pharmacy research group, Université catholique de Louvain, Brussels, Belgium.
Cliniques Universitaires Saint-Luc · BEUCLouvain · BEUniversity Medical Center Utrecht · NLRoyal College of Surgeons in Ireland · IEUniversité de Lille · FRUniversity College Cork · IEUniversity Hospital of Bern · CHUniversity of Bern · CH

Funding

Horizon 2020 6342388
6 · The paper itself

Abstract

backgroundComparisons of clinical trial findings in systematic reviews can be hindered by the heterogeneity of the outcomes reported. Moreover, the outcomes that matter most to patients might be underreported. A core outcome set can address these issues, as it defines a minimum set of outcomes that should be reported in all clinical trials in a particular area of research. The objective in this study was to develop a core outcome set for clinical trials of medication review in multi-morbid older patients with polypharmacy.

methodsFirstly, eligible outcomes were identified through a systematic review of trials of medication review in older patients (≥65 years) and interviews with 15 older patients. Secondly, an international three-round Delphi survey in four countries involving patients, healthcare professionals, and experts was conducted to validate outcomes to be included in the core outcome set. Consensus meetings were conducted to validate the results.

resultsOf the 164 participants invited to take part in the Delphi survey, 150 completed Round 1, including 55 patients or family caregivers, 55 healthcare professionals, and 40 experts. A total of 129 participants completed all three rounds. Sixty-four eligible outcomes were extracted from 47 articles, 32 clinical trial protocols, and patient interviews. Thirty outcomes were removed and one added after Round 1, 18 outcomes were removed after Round 2, and seven after Round 3. Results were discussed during consensus meetings. Consensus was reached on seven outcomes, which constitute the core outcome set: drug-related hospital admissions; drug overuse; drug underuse; potentially inappropriate medications; clinically significant drug-drug interactions; health-related quality of life; pain relief.

conclusionsWe developed a core outcome set of seven outcomes which should be used in future trials of medication review in multi-morbid older patients with polypharmacy.

Indexed as

PolypharmacyAgedComorbidityDelphi TechniqueHumansMedication AdherenceQuality of LifeSurveys and QuestionnairesConsensusCore outcome setDelphi surveyMedication reviewMulti-morbidityOlder patientsPolypharmacy

Identifiers

PMID29433501
PMCPMC5809844
OpenAlexW2786627110

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.